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T62171 |
HDAC8/BRPF1-IN-1
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Others
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HDAC8/BRPF1-IN-1 (Compound 23a) is a dual HDAC8 and BRPF1 inhibitor that acts on human HDAC8 (IC50: 443 nM) and human BRPF1 (Kd: 67 nM). HDAC8/BRPF1-IN-1 has low in vitro activity against HDAC1 and 6. |
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T74271 |
TRIM24/BRPF1-IN-2
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Others
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TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1, demonstrating IC50 values of 0.98 μM for TRIM24 and 1.16 μM for BRPF1, respectively. It exhibits strong binding affinity to the bromodomain... |
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T61727 |
HDAC6/8/BRPF1-IN-1
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Others
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HDAC6/8/BRPF1-IN-1 is a dual inhibitor that targets HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 n... |
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T1972 |
GSK-5959
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Epigenetic Reader Domain
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GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family... |
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T1973 |
PFI-4
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PFI4 |
Epigenetic Reader Domain
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PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor. |
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T3311 |
GSK6853
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Epigenetic Reader Domain
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GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain. |
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T16321 |
NI-42
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Epigenetic Reader Domain
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NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele... |
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TQ0083 |
NI-57
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Epigenetic Reader Domain
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NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively. |
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T13715L |
GSK9311
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Epigenetic Reader Domain
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GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control. |
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T13715 |
GSK9311 hydrochloride
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Epigenetic Reader Domain
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T11597 |
IACS-9571
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ASIS-P040 |
Epigenetic Reader Domain
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IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). |
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T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
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IACS-9571 Hydrochloride,ASIS-P040 Hydrochloride |
Epigenetic Reader Domain
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IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). |
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T72274 |
IACS-9571 hydrochloride
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ASIS-P040 hydrochloride |
Others
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IACS-9571 (ASIS-P040) hydrochloride is a potent, selective inhibitor of TRIM24 and BRPF1, demonstrating an IC50 of 8 nM for TRIM24, and dissociation constants (Kd) of 31 nM and 14 nM for TRIM24 and BRPF1, respectively. |
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T14502 |
BAY-299
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BAY299,BAY 299 |
Epigenetic Reader Domain
,
Carboxypeptidase
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BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with IC50s of 67 nM, 8 nM, and 106 nM, respectively. |
