Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 24,000 | |||
25 mg | 在庫あり | ¥ 49,000 | |||
50 mg | 在庫あり | ¥ 75,500 | |||
100 mg | 在庫あり | ¥ 118,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins. |
ターゲット&IC50 | BRD7:82 nM, BRPF3:260 nM, BRPF3:940 nM (kd), BRPF2:210 nM (kd), BRPF2:48 nM, BRPF1:40 nM (kd), BRPF1:7.9 nM, BRD9:1130 nM (kd), BRD9:310 nM, BRD4 BD1:4500 nM |
In vitro | NI-42 displays IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively. It has a Kd of 1130 nM for BRD9. |
分子量 | 353.39 |
分子式 | C18H15N3O3S |
CAS No. | 1884640-99-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (268.82mM)
You can also refer to dose conversion for different animals. 詳細
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NI-42 1884640-99-6 Chromatin/Epigenetic Epigenetic Reader Domain Inhibitor inhibit NI 42 NI42 inhibitor