TQ0083 |
NI-57
|
1883548-89-7
|
98%
|
|
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) ...
|
T17697 |
BRD7-IN-1
|
2448414-48-8
|
98%
|
|
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 through linkage to a VHL ligand, demonstrating potent activity against BRD7/9 w...
|
T4247 |
I-CBP112 hydrochloride
|
2147701-33-3
|
98%
|
|
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 t...
|
T9370 |
DCBP-1
|
2484739-25-3
|
98%
|
|
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 l...
|
T8932 |
GSK046
|
2474876-09-8
|
98%
|
|
GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD...
|
T9629 |
BRD4 Inhibitor-24
|
309951-18-6
|
98%
|
|
BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.
|
T60155 |
PBRM1-BD2-IN-7
|
2819989-68-7
|
98%
|
|
PBRM1-BD2-IN-7, a selective and cell-active inhibitor targeting the polybromo-1 (PBRM1) bromodomain, demonstrates inhibitory efficacy against PBRM1-BD2 with an I...
|
T8453 |
UNC1079
|
1418741-86-2
|
98%
|
|
UNC1079 is an selective L3MBTL3 domain inhibitor
|
T10641 |
C-82
|
1422253-37-9
|
98%
|
|
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
|
T13363 |
Y06137
|
2226534-49-0
|
98%
|
|
Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-res...
|
T29214 |
ZEN-3694
|
1643947-30-1
|
98%
|
|
ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and can be...
|
T15424 |
GSK1379725A
|
1802251-00-8
|
98%
|
|
GSK1379725A is a selective BPTF ligand (Kd: 2.8 uM). It also shows no binding activity for Brd4.
|
T9703L |
GSK778 hydrochloride
|
2863657-79-6
|
98%
|
|
GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 ...
|
T16072 |
MI-538
|
1857417-10-7
|
98%
|
|
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
|
T3311 |
GSK6853
|
1910124-24-1
|
|
|
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
|
T3217 |
PF-CBP1 hydrochloride
|
2070014-93-4
|
|
|
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains w...
|
T28628 |
RVX-297
|
1044871-04-6
|
|
|
RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family ...
|
T5440 |
Dbet57
|
1883863-52-2
|
|
|
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive ...
|
T12112 |
MS402
|
1672684-68-2
|
100%
|
|
MS402 is a novel BD1-selective BET BrD inhibitor.
|
T60156 |
PBRM1-BD2-IN-2
|
2819989-57-4
|
100%
|
|
PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targ...
|