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T10708 |
CCR1 antagonist 6
|
|
CCR
|
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CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM). |
|
T15253 |
CCX354
|
CCR1 antagonist 1,CCX-354,CCX 354 |
CCR
|
|
CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis. |
|
T30258 |
AZD-4818
|
CCR1 antagonist |
CCR
|
|
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. |
|
T77349 |
CCR1/5/8 activator 1
|
|
Phospholipase
|
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CCR1/5/8 activator 1 is a cytoplasmic phospholipase A inhibitor with antifungal activity. |
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T10710 |
CCR1 antagonist 9
|
|
CCR
|
|
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). |
|
T10709 |
CCR1 antagonist 7
|
|
CCR
|
|
CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1]. |
|
T14899 |
CCR1 antagonist 8
|
|
CCR
|
|
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay). |
|
T64242 |
CCR1 antagonist 11 hydrochloride
|
|
|
|
CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist that acts on hCCR1 (IC50: 0/.03 μM), mCCR1 (IC50: 0.58 μM), rCCR1 (IC50: 0.32 μM). 11 hydrochloride can be used to study rheumatoid arthritis an... |
|
T28072 |
MLN-3897
|
AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897 |
CCR
|
|
MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell survival and proliferation. |
|
T11699 |
J-113863
|
|
CCR
|
|
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor... |
|
T2375 |
BX471
|
BX 471,BX-471,ZK-811752 |
CCR
|
|
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist. |
|
T26861 |
BMS-817399
|
BMS817399 |
CCR
|
|
BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis. |
|
T28072L |
MLN-3897 TFA
|
MLN-3897 TFA(1010731-97-1 Free base) |
CCR
|
|
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes. |
|
T3188 |
RE-640
|
|
CCR
,
Parasite
|
|
NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities. |
|
TQ0283 |
RS102895
|
|
CCR
|
|
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1. |
|
T5384 |
RS 504393
|
|
CCR
|
|
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1). |
|
T14845 |
BX471 hydrochloride
|
ZK-811752 hydrochloride |
Others
|
|
|
|
T23492 |
UCB 35625
|
|
Others
|
|
chemokine CCR1 and CCR3 receptor antagonist |
|
T31061 |
CP-481715
|
CP 481,715,CP-481,715,CP481715,CP481,715 |
|
|
CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases. |
|
T26849 |
BMS-457
|
|
|
|
BMS-457 is a potent, CCR1-selective antagonist. |
|
T73371 |
BAY-3153
|
|
|
|
BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) . |
|
T71905 |
BX-513 HCl
|
|
|
|
BX-513 HCl is a selective CCR1 receptor antagonist. |
|
T68427 |
MLN-3897 citrate
|
|
|
|
MLN-3897 citrate is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. |
|
T41016 |
Vercirnon sodium
|
GSK-1605786 sodium,CCX282-Bsodium,Traficet-ENsodium |
|
|
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent CCR9 antagonist. It effectively inhibits CCR9-mediated calcium mobilization and chemotaxis in Molt-4 cells, exhibiting IC50 values of 5.4 nM... |
|
T12773 |
RS102895 hydrochloride
|
|
Others
,
5-HT Receptor
,
CCR
|
|
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM). |
|
T17274 |
YM022
|
|
CCR
|
|
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki v... |
