CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Cat. No.	製品名	CAS No.	Purity
T60336	CCR4 antagonist 3-1	1957-01-3	98%
T60336	CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 val...
T3188	NSC5844	140926-75-6	98%
T3188	NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T13114	CCR2 antagonist 4	226226-39-7	98%
T13114	CCR2 antagonist 4 is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).
T14688	BMS CCR2 22	445479-97-0	98%
T14688	BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
TN1599	Eburicoic acid	560-66-7	98%
TN1599	Eburicoic acid exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about...
T4674	SB297006	58816-69-6	98%
T4674	SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ....
T3327	Artemotil	75887-54-6	98%
T3327	Arteether is a new, fast-acting antimalarial drug.
T11699	J-113863	353791-85-2	98%
T11699	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...
T15253	CCX354	1010073-75-2	98%
T15253	CCX354 is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.
T7624	DAPTA	106362-34-9	98%
T7624	DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
T10712	CCR2 antagonist 3	1380100-86-6	98%
T10712	CCR2 antagonist 3 is an antagonist of CCR2.
T21870	C-021	864289-85-0	98%
T21870	C 021 dihydrochloride is a potent CCR4 antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 n...
T30260	AZD-5672	780750-65-4	98%
T30260	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
T9983	CCR8 antagonist 1	723304-76-5	98%
T9983	CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.
T3435	Vicriviroc maleate	599179-03-0	98%
T3435	Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in cl...
T14909	CCX140	1100318-47-5	98%
T14909	CCX140 (CCX140-B) is an antagonist of CCR2.
T24700	R243	688352-84-3	98%
T24700	R243 is CCR8 signaling and chemotaxis inhibitor.
TQ0103	INCB3344	1262238-11-8	98%
TQ0103	INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM...
T10425	AZ084	929300-19-6	98%
T10425	AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T10708	CCR1 antagonist 6	2436773-01-0	98%
T10708	CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).