Powder: -20°C for 3 years | In solvent: -80°C for 1 year
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.
説明 | J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. |
ターゲット&IC50 | CCR3:0.58 nM (IC50, Human CCR3), CCR3:460 nM (IC50, Mouse CCR3), CCR1:0.9 nM (IC50, Human CCR1), CCR1:5.8 nM (IC50, Mouse CCR1) |
In vitro | The chemotaxis of the following cells were inhibited by J-113863. Modified Vaccinia virus Ankara (MVA) but not MVA and vaccinia virus (VACV) infected MH-S cells increase the expression of the CXCR2 acting chemokine CXCL2. MH-S cells constitutively produce CCL2 and CCR1 acting chemokines CCL3, CCL5 and CCL9. Consequently, supernatants of mock treated and virus infected MH-S cells induce chemotaxis of murine promyelocyte MPRO cells and human monocytic THP-1 cells at the same level. However, supernatants of MVA infected MH-S cells significantly increase chemotaxis of the CCR2 deficient human monocytic cell line U-937. |
In vivo | J-113863 treatment improves paw inflammation and joint damage, and dramatically decreases cell infiltration into joints in arthritic mice. |
分子量 | 655.44 |
分子式 | C30H37Cl2IN2O2 |
CAS No. | 353791-85-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.56 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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J-113863 353791-85-2 Immunology/Inflammation Microbiology/Virology CCR Inhibitor inhibit rheumatoid CCR1 CCR3 J 113863 CC chemokine receptor Chemotaxis collagen arthritis J113863 CD18 anti-inflammatory inhibitor