|
T25394 |
ETB067
|
ETB-067,ETB 067 |
|
|
ETB067, an H-89 analog, acts as a PKA and AKT1 inhibitor with specificity on no longer inhibiting CAMK2B and neither affecting viability of mice nor causing any detectable tissue damage at the dose given. |
|
T3474 |
RO 46-8443
|
|
Endothelin Receptor
|
|
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. |
|
T2561 |
Macitentan
|
ACT-064992 |
Apoptosis
,
Endothelin Receptor
|
|
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). |
|
T73099 |
Etbicyphat
|
Trimethylopropane phosphate |
|
|
Etbicyphat (Trimethylopropane phosphate), a potent competitive antagonist of GABA(A) receptors, binds to GABA(A)-benzodiazepine receptors and induces epileptiform activities in hippocampal CA1 neurons. |
|
T7817 |
Aprocitentan
|
ACT-132577 |
Endothelin Receptor
|
|
Aprocitentan (ACT-132577) is ETA and ETB antagonist . |
|
T10595 |
BQ-788
|
BQ788 |
Endothelin Receptor
|
|
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press... |
|
TP2262L |
IRL-1038 acetate
|
IRL-1038 acetate(144602-02-8 Free base) |
Endothelin Receptor
|
|
IRL-1038 acetate is a potent ETB endothelin receptor antagonist. |
|
T15595L |
IRL-1620 acetate
|
IRL-1620 acetate（142569-99-1 free base） |
Endothelin Receptor
|
|
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM. |
|
T6258 |
Zibotentan
|
ZD4054 |
Apoptosis
,
Endothelin Receptor
|
|
Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. |
|
T19309L1 |
Endothelin 1 (swine, human) acetate
|
Endothelin 1 (swine, human) acetate(117399-94-7 free base) |
Endothelin Receptor
|
|
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor and acts through two types of receptors ETA and ETB. |
|
T6265 |
Bosentan (hydrate)
|
Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 |
Endothelin Receptor
|
|
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. |
|
T22540L |
Ac-Endothelin-1 (16-21), human acetate
|
|
Others
|
|
Ac-Endothelin-1 (16-21), human acetate, the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which i... |
|
T6264 |
Bosentan
|
Actelion,Ro 47-0203,Benzenesulfonamide |
Endothelin Receptor
|
|
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th... |
|
T5458 |
Darusentan
|
Lu-135252 |
Endothelin Receptor
|
|
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries |
|
T0750 |
Sulfisoxazole
|
NU-445,Sulfafurazole |
Endothelin Receptor
,
Antibacterial
,
Antibiotic
,
Autophagy
|
|
Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting ... |
|
T17064 |
Tezosentan
|
RO 610612 |
Others
|
|
Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively). |
|
T12382 |
PD-159020
|
|
Others
|
|
PD-159020 is a non-selective antagonist of ETA/ETB(hETA and hETB with IC50s of 30 and 50 nM , respectively). |
|
T10595L |
BQ-788 sodium salt
|
|
Others
|
|
|
|
T15595 |
IRL-1620
|
|
Others
|
|
IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM). |
|
T15596 |
IRL 2500
|
|
Endothelin Receptor
|
|
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor. |
|
T36008 |
Nebentan potassium
|
YM598 |
Endothelin Receptor
|
|
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurolog... |
|
TP1706 |
BQ-3020 TFA (143113-45-5 free base)
|
BQ-3020 TFA |
|
|
BQ-3020 (TFA) is a selective ETB receptor agonist that inhibits [125I] et-1 binding to the ETB receptor in the cerebellum with a 0.2nm IC50, causing vasoconstriction. |
|
TP2120 |
Sarafotoxin S6c
|
|
|
|
Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively). |
|
T14068 |
A-192621
|
|
Others
|
|
A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and it also causes elevation of arteri... |
|
T10351 |
Aprocitentan D4
|
ACT-132577 D4 |
Others
|
|
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2... |
|
TP2262 |
IRL-1038
|
|
Others
|
|
ETB endothelin receptor antagonist |
|
TP2099 |
[Ala1,3,11,15]-Endothelin
|
|
|
|
Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively). |
|
TP1512 |
[Ala1,3,11,15]-Endothelin TFA
|
|
|
|
[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for ... |
|
TP1465 |
IRL-1620 TFA (142569-99-1 free base)
|
IRL-1620 TFA |
|
|
IRL-1620 (TFA) is a potent selective endothelin receptor B (ETB) agonist with a Ki value of 16pm. |
|
T36007 |
Nebentan
|
|
|
|
Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA... |
|
T75771 |
BQ-3020 TFA
|
|
|
|
BQ-3020 (TFA) is a selective ETB receptor agonist that obstructs [125I]ET-1 binding to the ETB receptor in the cerebellum, exhibiting an IC50 of 0.2 nM, and induces vasoconstriction [1]. |
|
T9621 |
N-(6-chloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidin-4-yl)-5-Methylpyridine-2-sulfonamide
|
|
Others
|
|
N-(6-chloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidin-4-yl)-5-Met inhibits endothelin binding to membranes from CHO cells carrying human ETA receptor and human ETB receptor with IC50 of 268nM and 1810nM, respectivel... |
|
T19309 |
Endothelin 1 (swine, human)
|
|
Others
|
|
Endothelin 1 (swine, human), a synthetic peptide mirroring the sequence of both human and swine Endothelin 1, functions as a robust endogenous vasoconstrictor by interacting with two receptor types, ETA and ETB. |
|
TMIH-0383 |
N-Despropyl Macitentan-d4
|
|
|
|
N-Despropyl Macitentan-d4 is a deuterated compound of N-Despropyl Macitentan. N-Despropyl Macitentan has a CAS number of 1103522-45-7. Aprocitentan is ETA and ETB antagonist . |
|
T11934 |
Macitentan-d4
|
Macitentan D4,ACT-064992 D4 |
Endothelin Receptor
|
|
Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer... |
|
T11935 |
Macitentan (n-butyl analogue)
|
|
Others
|
|
Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros... |
|
T75249 |
IRL-1620 TFA
|
|
|
|
IRL-1620 (TFA) is a potent, selective agonist for the endothelin receptor type B (ETB) with an affinity (K i) of 16 pM. |
|
T36878 |
Sclerotiorin
|
|
|
|
Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 μM. Sclerotiorin also exhibits a number of other activities including inhibition... |
|
T27647 |
J-104132
|
L753037,L 753037,J104132,J 104132,L-753037 |
|
|
J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inosito... |
|
T75772 |
[Ala1,3,11,15]-Endothelin (53-63) (TFA)
|
|
|
|
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is a selective ET B agonist with IC50 values ranging from 0.33 nM to 0.61 nM, demonstrating its preference for ET B receptors. It is utilized in the study of vasoconstriction. |
|
T22540 |
Ac-Endothelin-1 (16-21), human
|
|
Others
|
|
ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which is a highly cons... |
|
T78096 |
BQ-3020 ammonium
|
|
Endothelin Receptor
|
|
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2 nM and induces vasoconstriction in rabbit pulmonary arterie... |
|
T75731 |
Endothelin 1 (swine, human) (TFA)
|
|
|
|
Endothelin 1 (swine, human) (TFA) is a synthetic peptide mirroring the sequence of the potent endogenous vasoconstrictor found in both human and swine Endothelin 1. It operates via two receptor types, ET A and ET B [1]. |
|
T75807 |
Sarafotoxin S6a TFA
|
|
|
|
Sarafotoxin S6a TFA, an analogue of sarafotoxin, functions as an endothelin receptor agonist with an ET_A/ET_B selectivity profile akin to Endothelin-3. It demonstrates an EC_50 of 7.5 nM in stimulating the pig coronary ... |
|
T73820 |
Bosentan-d4
|
|
|
|
Bosentan-d4, the deuterium-labeled variant of Bosentan, serves as a competitive dual antagonist against endothelin-1 (ET) by targeting both ET A and ET B receptors. It exhibits binding affinities with K i values of 4.7 n... |
|
T76081 |
Endothelin 1 (swine, human), Alexa Fluor 488-labeled
|
|
|
|
Endothelin 1 (swine, human), Alexa Fluor 488-labeled, is a synthetic peptide corresponding to the sequence of human and swine Endothelin 1, a powerful endogenous vasoconstrictor, and is tagged with Alexa Fluor 488 for fl... |
|
T30501 |
BMS-193884
|
BMS193884,BMS 193884 |
|
|
BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension. |
