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T21881 |
Fluconazole hydrate
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Fluconazole (hydrate) is a triazole antifungal agent used for the oral treatment and prevention of both superficial and systemic fungal infections, including but not limited to balanitis, various Candida infections, Cryp... |
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T61960 |
Fluconazole mesylate
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Fluconazole (mesylate) is a triazole antifungal drug. Fluconazole (mesylate) can used in the treatment and prevention of superficial and systemic fungal infections |
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T27617 |
Inz-1
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P450
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Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the path... |
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T5328 |
Fosfluconazole
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Antifungal
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Fosfluconazole is water-soluble phosphate prodrug of fluconazole. Fluconazole is an antifungal drug. |
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T11991 |
Mefentrifluconazole
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P450
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Antifungal
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Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ... |
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T2213 |
Terconazole
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Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470 |
Antifection
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Antifungal
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Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damag... |
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T8826 |
3-AMINO-1,2,4-TRIAZINE
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Others
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3-AMINO-1,2,4-TRIAZINE is an aromatic bioactive compound. It has been used to synthesize a variety of drugs, including the antifungal drug fluconazole, the anti-inflammatory drug ibuprofen and the anticancer drug paclita... |
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T38240 |
2,6-Dichlorodiphenylamine
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Antibacterial
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2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1... |
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T35297 |
ZD 0870
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D 0870,D0870,ZD0870 |
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ZD 0870, used to treat infections caused by fluconazole-resistant candida albicans. |
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T63478 |
Antifungal agent 12
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Antifungal agent 12 is a new fluconazole-like compound that exhibits good antifungal effects. |
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T79709 |
PK-10
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PK-10, when combined with Fluconazole, exhibits potent synergistic antifungal activity against multiple Fluconazole-resistant Candida albicans strains. This compound impedes hyphae formation, stimulates reactive oxygen s... |
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T63157 |
Antifungal agent 16
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Antifungal agent 16 has antimicrobial activity comparable to that of ciprofloxacin and has higher antifungal activity than fluconazole. |
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T63802 |
Antifungal agent 35
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Antifungal agent 35 is an effective antifungal agent that potentiates the antifungal activity of fluconazole against C. albicans. |
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T79413 |
Antifungal agent 73
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Antifungal agent 73 (compound A32) effectively combats azole-resistant candidiasis by disrupting the fungal cell wall and membrane. It demonstrates potent in vivo activity against pathogenic fungi, including fluconazole-... |
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T61188 |
Chitin synthase inhibitor 2
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Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 value of 0.09 mM and a K i value of 0.12 mM. This compound exhibits antimicrobial activities in vitro and demonstrat... |
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T79384 |
Antifungal agent 72
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Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via disruption of the Pdr1-KIX interaction (K i : 11.7 μM). It exhibits... |
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T62167 |
BI-10
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BI-10 is an antifungal compound that, in combination with fluconazole, inhibits mycelial growth, accumulates ROS, reduces mitochondrial membrane potential (MMP) and alters membrane permeability. |
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T64235 |
Antifungal agent 25
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Antifungal agent 25 is an effective, broad-spectrum, metabolically stable antifungal agent in vivo. antifungal agent 25 exhibits antifungal effects against both Candida albicans and fluconazole-resistant Candida albicans... |
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T75178 |
Antifungal agent 55
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Antifungal agent 55 (Compound A07) effectively inhibits Fluconazole-resistant strains of Candida albicans, demonstrating greater efficacy than Miconazole. It exhibits minimum inhibitory concentrations (MIC) values rangin... |
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T70029 |
Ibrexafungerp citrate
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Ibrexafungerp citrate is a triterpenoid antifungal. Similarly to echinocandins, it inhibits the synthesis of 1,3-β-d-glucan. However, it binds to a different site on the enzyme than echinocandins, resulting in limited cr... |
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T75179 |
Antifungal agent 56
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Antifungal agent 56 (compound A09) is a potent antifungal agent, demonstrating superior efficacy against Fluconazole-resistant strains and outperforming Miconazole. It effectively inhibits Candida albicans strains, with ... |
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T75180 |
Antifungal agent 57
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Antifungal Agent 57 (Compound A19) demonstrates potent efficacy against Fluconazole-resistant strains, outperforming Miconazole. It effectively inhibits Candida albicans strains, exhibiting minimum inhibitory concentrati... |
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T75181 |
Antifungal agent 58
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Antifungal agent 58 (compound A21) exhibits high potency against Fluconazole-resistant strains and outperforms Miconazole in effectiveness. It inhibits Candida albicans strains with minimum inhibitory concentration (MIC)... |
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T68562 |
FTR-1335
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FTR1335 is a CaNMT inhibitor (IC50 = 0.49 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains). They function by inhibi... |
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T35902 |
Milbemycin A4 oxime
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Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilar... |
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T79467 |
Antifungal agent 60
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Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates ... |
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T75177 |
Antifungal agent 54
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Antifungal agent 54 (compound A05) serves as a potent inhibitor against Fluconazole-resistant strains, outperforming Miconazole in efficacy. It exhibits considerable activity against Candida albicans, with minimum inhibi... |
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T62098 |
Antifungal agent 28
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Antifungal agent 28 (compound 18) is a selective and potent antifungal agent that disrupts mature Candida biofilms and inhibits pathogenic strains of Candida albicans and non-Candida albicans, including fluconazole-resis... |
