Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluconazole (UK-49858) is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 8,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 13,500 | |||
500 mg | 在庫あり | ¥ 16,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 7,000 |
説明 | Fluconazole (UK-49858) is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. |
In vitro | Fluconazole significantly affects the fungicidal activity of 5-fluorocytosine against cryptococcal meningitis in mice. It is highly effective in extending the survival period of rats infected with representative Candida strains. Compared to the activity of each drug used alone, the combination of fluconazole with 5-fluorocytosine and amphotericin B exhibits markedly improved activity against cryptococcal meningitis. |
In vivo | Under physiological pH conditions, Fluconazole's activity against 35 Candida albicans strains is 16-fold lower than that of Ketoconazole. When used in combination with Amphotericin B, Fluconazole exhibits synergistic effects against C. albicans cells, yet it does not alter the anti-biofilm activity of AmB. Fluconazole, alongside Caspofungin, antagonizes biofilm formation but has no effect on planktonic cells. Significantly, Fluconazole reduces ergosterol levels in C. albicans planktonic cells, leading to membrane perturbation. Its activity is less sensitive to acidic conditions compared to Ketoconazole. Additionally, the combined use of Fluconazole and Itraconazole shows effective activity against various Candida species, including Fluconazole-resistant strains of C. albicans and Candida tropicalis. |
別名 | UK-49858 |
分子量 | 306.27 |
分子式 | C13H12F2N6O |
CAS No. | 86386-73-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 30.6 mg/mL (100 mM)
DMSO: 30.6 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Fluconazole 86386-73-4 Microbiology/Virology Antibiotic Antifection Antifungal Agent Inhibitor albicans UK49858 UK-49858 Fungal fungi,Candida kefyr Triazole Candida C. albicans UK 49858 inhibit inhibitor