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T78212 |
RMC-9805
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KRAS G12D inhibitor 18,KRAS G12D IN 18 |
Others
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RMC-9805 is a potent KRAS G12D inhibitor with potential anti-tumor and inhibitory activity against tumor cell proliferation for the study of pancreatic cancer. |
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T78170 |
Kras4B G12D-IN-1
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Ras
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Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mut... |
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T9674 |
KRAS G12D inhibitor 1
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KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D with an IC 50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1]. |
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T40282 |
KRAS G12D inhibitor 7
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KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D. |
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T40281 |
KRAS G12D inhibitor 6
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KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D. |
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T40246 |
KRAS G12D inhibitor 5
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KRAS G12D inhibitor 5 is a KRAS G12D inhibitor for the potential treatment of pancreatic cancer. |
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T77804 |
KRAS G12D mutation regulator 4
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KRAS G12D mutation regulator 4 can be used in studies about Ras. |
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T64178 |
KRAS G12D inhibitor 13
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KRAS G12D inhibitor 13 is a potent inhibitor of KRAS G12D. KRAS G12D inhibitor 13 has shown potential for the investigation of KRAS G12D-mediated cancers. |
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T79072 |
KRAS G12D modulator-1
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Ras
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KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is utilized in cancer research [1]. |
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T63028 |
KRAS G12D inhibitor 12
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KRAS G12D inhibitor 12 is an effective inhibitor of KRAS G12D. The Ras protein family is an important intracellular signaling molecule, which plays an important role in growth and development. KRAS G12D inhibitor 12 has ... |
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T64031 |
KRAS G12D inhibitor 9
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KRAS G12D inhibitor 9 is a potent inhibitor of KRAS G12D. Among them, the RAS protein family is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 9 ... |
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T72345 |
KRAS G12D inhibitor 10
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KRAS G12D Inhibitor 10 is a potent agent targeting the KRAS G12D mutation, a variant in the Ras protein family crucial for cellular growth and development. This compound shows promise for investigating cancers mediated b... |
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T74607 |
KRAS G12D inhibitor 15
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KRAS G12D inhibitor 15 is a potent inhibitor specifically targeting the KRAS G12D mutation. It holds potential for research into numerous diseases or disorders, including cancer and its metastases[1]. |
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T72355 |
KRAS G12D inhibitor 16
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KRAS G12D Inhibitor 16 is a potent compound targeting the KRAS G12D and its mutation, exhibiting inhibitory activity with IC50 values of 0.7 nM and 0.35 μM, respectively. It is utilized in researching various malignant t... |
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T62228 |
KRAS G12D inhibitor 14
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Ras
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KRAS G12D inhibitor 14 is a potent inhibitor of KRAS G12D that binds KRAS G12D protein (Kd: 33 nM). KRAS G12D inhibitor 14 inhibits the active form of KRAS G12D (KRAS G12D-GTP), but not KRAS G13D. |
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T63577 |
KRAS G12D inhibitor 11
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KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins are important intracellular signaling molecules that play an important role in growth and development, and KRAS G12D inhibitor 11 has ... |
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T72394 |
KRAS G12D inhibitor 3
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KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less than 500 nM. |
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T74663 |
KRAS G12D inhibitor 17
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KRAS G12D Inhibitor 17 (example 8), a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, acts as a proteolysis targeting chimera (PROTAC) [1], specifically inducing degradation of the G12D-mutation KRAS protein. |
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T73828 |
KRAS G12D inhibitor 3 TFA
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KRAS G12D Inhibitor 3 TFA, exhibiting an inhibitory concentration (IC50) of less than 500 nM, is effective as an antitumor agent. |
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T9303 |
MRTX1133
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Ras
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MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors. |
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T11224 |
Rineterkib
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ERK-IN-1 |
ERK
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Raf
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T9533 |
BC-LI-0186
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4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
Others
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BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protei... |
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TP2358 |
KRPEP-2D acetate
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Raf
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KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family and an attractive cancer therapeutic target. |
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T72062 |
BI-2865
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Ras
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BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cel... |
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T5469 |
K-Ras-IN-1
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Raf
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Ras
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K-Ras-IN-1 is a K-Ras inhibitor. |
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T8756 |
KRAS inhibitor-9
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DUN09716 |
Apoptosis
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Ras
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KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ... |
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T79092 |
TH-Z827
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Ras
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TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Additionally, it disrupts the KRAS(G12D)-CRAF interaction with an I... |
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T78661 |
TH-Z835
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Ras
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TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM. It effectively hampers both mantGMPPNP/GPPNP and GPPNP/mantGMPPNP exchanges [1]. |
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T37130 |
MRTX1133 formic
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MRTX1133 is a highly selective, first-in-class inhibitor of KRAS G12D. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tu... |
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T64000 |
MRTX-EX185
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MRTX-EX185 is an effective inhibitor of GDP-loaded KRAS and KRAS (G12D) with an IC50=90 nM for KRAS (G12D). MRTX-EX185 is also capable of binding GDP-loaded HRAS. |
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T82348 |
GAGGVGKSAL
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GAGGVGKSAL, a wild-type KRAS G12D 10mer peptide, serves as an immunogenic neoantigen in cancer immunotherapy research [1]. |
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T82352 |
GADGVGKSAL
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GADGVGKSAL, a mutant KRAS G12D 10mer peptide, serves as an immunogenic neoantigen in cancer immunotherapy research [1]. |
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T63118 |
SOS1-IN-8
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SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM). |
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T82349 |
GAGGVGKSA
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GAGGVGKSA, a wild-type KRAS G12D 9mer peptide, serves as an immunogenic neoantigen pivotal for cancer immunotherapy research [1]. |
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T82353 |
GADGVGKSA
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GADGVGKSA, a mutant KRAS G12D 9mer peptide, serves as an immunogenic neoantigen for cancer immunotherapy research [1]. |
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T62923 |
SOS1-IN-7
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SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM). |
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T74755 |
TUS-007
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TUS-007, a modified CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) molecule originally derived from a proteasome inhibitor, scarcely affects proteasome activity. It is a potent, orally active degrader... |
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T63044 |
SOS1-IN-6
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SOS1-IN-6 (compound 33-P1) is a potent inhibitor of SOS1, acting on SOS1-G12D (IC50: 14.9 nM) and SOS1-G12V (IC50: 73.3 nM). |
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T79673 |
LUNA18
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Ras
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LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation. It is utilized in cancer research [1]. |
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T79800 |
Pan-KRAS-IN-2
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Ras
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Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly... |
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T72659 |
KRAS inhibitor-3
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KRAS inhibitor-3, an efficacious inhibitor of both wild-type (WT) and oncogenic KRAS mutations, exhibits high-affinity binding (K D: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, and 0.74 μM for KRAS... |
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T76059 |
SAH-SOS1A TFA
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SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA di... |
