ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

Cat. No.	製品名	CAS No.	Purity
T1144	Lidocaine hydrochloride	73-78-9	98%
T1144	Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
T0304	Methylthiouracil	56-04-2	98%
T0304	Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T21295	BIX02189	1265916-41-3	98%
T21295	BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
T4S2063	Tetrahydrocoptisine	4312-32-7	98%
T4S2063	1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T6948	Pluripotin	839707-37-8	98%
T6948	Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
T3668	Galangin	548-83-4	98%
T3668	Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T6S0655	Corynoxeine	630-94-4	98%
T6S0655	1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and ...
TN3967	Epieriocalyxin A	191545-24-1	98%
TN3967	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
T5S0168	Atractylenolide II	73069-14-4	98%
T5S0168	1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
T2029	Bohemine	189232-42-6	98%
T2029	Bohemine is a cyclin-dependent kinase inhibitor.
T5358	Longdaysin	1353867-91-0	98%
T5358	Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).
T4444	A-674563 HCl (552325-73-2(free base))		98%
T4444	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T12069	MK-8353	1184173-73-6	98%
T12069	MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)
T72662	NMDAR/TRPM4-IN-2	2243506-33-2	98%
T72662	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T4S2326	Cornuside	131189-57-6	98%
T4S2326	1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en...
T36674	DMU-212	134029-62-2	98%
T36674	DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic...
TN1560	Dehydroeffusol	137319-34-7	98%
TN1560	Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties, it may antagonize the spasmogenic activity of various agents, and therefore, could be a...
TN2316	Xanthyletin	553-19-5	98%
TN2316	Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.