Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 52,500 |
5 mg | 在庫あり | ¥ 132,000 |
10 mg | 在庫あり | ¥ 189,000 |
25 mg | 在庫あり | ¥ 289,500 |
50 mg | 在庫あり | ¥ 388,000 |
100 mg | 在庫あり | ¥ 523,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 133,000 |
説明 | BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM. |
In vitro | BI-2865 inhibits the proliferation of BaF3 cells expressing G12C, G12D or G12V mutant KRAS in the presence of IL-13 with a mean IC50 of approximately 140 nM.[1] |
分子量 | 465.57 |
分子式 | C23H27N7O2S |
CAS No. | 2937327-93-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (483.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BI-2865 2937327-93-8 GPCR/G Protein MAPK Ras BI 2865 BI2865 Inhibitor inhibitor inhibit