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T27617 |
Inz-1
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P450
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Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the path... |
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T1887 |
Inauhzin
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INZ |
Sirtuin
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Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54... |
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T15587 |
Inz-5
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Others
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Inz-5 is a fungal-selective inhibitor of mitochondrial cytochrome bc1. Inz-5 impairs fungal virulence. It also prevents the evolution of drug resistance. |
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T27618 |
Inz-4
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Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1. |
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T25742 |
Linzagolix choline
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GNRH Receptor
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Linzagolix choline is an orally available non-peptide gonadotropin-releasing hormone (GnRH) antagonist. It can be used to study pain associated with uterine fibroids and endometriosis. |
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T38144 |
Elinzanetant
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Neurokinin receptor
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Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion. |
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T62304 |
Minzasolmin
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(R)-NPT200-11,UCB0599,DLX-313 |
Others
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Minzasolmin(DLX-313) is an alpha-synuclein misfolding inhibitor for the study of Parkinson's disease. |
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T0142 |
Brinzolamide
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AL-4862 |
Carbonic Anhydrase
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Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor. |
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T27837 |
Linzagolix
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GNRH Receptor
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Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) which is under development by Kissei Pharmaceutical and ObsEva for the treatment of uterine fibroids,... |
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T35713 |
N-desethyl Brinzolamide (oxalate)
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N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively).
1.Kim, C.-Y., Whittington, D.A., Chang... |
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T31240 |
Deacetoxyvinzolidine
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KAR-2,KAR2,KAR 2 |
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Deacetoxyvinzolidine is a bioactive agent. |
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T37403 |
O-desmethyl Brinzolamide (hydrochloride)
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O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1
1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Des... |
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T64241 |
Brinzolamide hydrochloride
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Brinzolamide (AL-4862) hydrochloride is a selective inhibitor (IC50: 3.2 nM) of carbonic anhydrase II. Brinzolamide hydrochloride inhibits ciliary CA-II and reduces atrial fluid secretion, thereby reducing intraocular pr... |
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T76906 |
Anrukinzumab
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Anrukinzumab (IMA-638), a humanized anti-IL-13 monoclonal antibody, effectively reduces lung inflammation in cynomolgus monkeys and shows potential in the studies of ulcerative colitis (UC) and asthma [1] [2] [3]. |
