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Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T60064 WAY-270360 476633-98-4 98%
WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.
TN1296 5-Feruloylquinic acid 40242-06-6 98%
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases asso...
TN7093 N-Caffeoyltryptophan 109163-69-1 98%
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7...
T12918 SIRT-IN-1 1431411-60-7 98%
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T22595 B2 115687-05-3 98%
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
T12922 Sirtuin modulator 1 2070015-26-6 98%
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.
T79903 Sirtuin-1 inhibitor 1 945114-10-3 98%
Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.
T7058 Selisistat S-enantiomer 848193-68-0
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
T2750 Ginkgolide C 15291-76-6
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
T50080 MC2184 74901-20-5
MC2184 is the inhibitor of human recombinant SIRT1.
T16932 SRT 2183 1001908-89-9 100%
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T64529 MDL-800 2275619-53-7 100%
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
T8480 Tenovin-6 Hydrochloride 1011301-29-3 100%
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
T28543 RK-9123016 955900-27-3 100%
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
T77697 BML-278 120533-76-8 100%
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
T4108 3-TYP 120241-79-4 100.00%
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
T9320 YK-3-237 1215281-19-8 96.38%
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative e...
T22094 JGB1741 1256375-38-8 97.24%
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleava...
T2160 Suramin Sodium Salt 129-46-4 97.47%
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
T8346 SRT 1460 925432-73-1 97.62%
SRT 1460 is a SIRT1 activator.
WAY-270360
T60064
WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.
5-Feruloylquinic acid
TN1296
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases asso...
N-Caffeoyltryptophan
TN7093
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7...
SIRT-IN-1
T12918
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
B2
T22595
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
Sirtuin modulator 1
T12922
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.
Sirtuin-1 inhibitor 1
T79903
Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.
Selisistat S-enantiomer
T7058
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
Ginkgolide C
T2750
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
MC2184
T50080
MC2184 is the inhibitor of human recombinant SIRT1.
SRT 2183
T16932
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
MDL-800
T64529
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
Tenovin-6 Hydrochloride
T8480
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
RK-9123016
T28543
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
BML-278
T77697
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
3-TYP
T4108
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
YK-3-237
T9320
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative e...
JGB1741
T22094
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleava...
Suramin Sodium Salt
T2160
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
SRT 1460
T8346
SRT 1460 is a SIRT1 activator.
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