| TN1296 |
5-Feruloylquinic acid
|
40242-06-6
|
98%
|
|
|
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases asso...
|
| TN7093 |
N-Caffeoyltryptophan
|
109163-69-1
|
98%
|
|
|
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7...
|
| T12918 |
SIRT-IN-1
|
1431411-60-7
|
98%
|
|
|
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
|
| T22595 |
B2
|
115687-05-3
|
98%
|
|
|
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
|
| T12922 |
Sirtuin modulator 1
|
2070015-26-6
|
98%
|
|
|
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.
|
| T79903 |
Sirtuin-1 inhibitor 1
|
945114-10-3
|
98%
|
|
|
Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.
|
| T7058 |
Selisistat S-enantiomer
|
848193-68-0
|
|
|
|
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
|
| T2750 |
Ginkgolide C
|
15291-76-6
|
|
|
|
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
|
| T50080 |
MC2184
|
74901-20-5
|
|
|
|
MC2184 is the inhibitor of human recombinant SIRT1.
|
| T16932 |
SRT 2183
|
1001908-89-9
|
100%
|
|
|
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
|
| T64529 |
MDL-800
|
2275619-53-7
|
100%
|
|
|
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
|
| T8480 |
Tenovin-6 Hydrochloride
|
1011301-29-3
|
100%
|
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
|
| T28543 |
RK-9123016
|
955900-27-3
|
100%
|
|
|
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
|
| T77697 |
BML-278
|
120533-76-8
|
100%
|
|
|
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
|
| T4108 |
3-TYP
|
120241-79-4
|
100.00%
|
|
|
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
|
| T9320 |
YK-3-237
|
1215281-19-8
|
96.38%
|
|
|
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative e...
|
| T22094 |
JGB1741
|
1256375-38-8
|
97.24%
|
|
|
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleava...
|
| T2160 |
Suramin Sodium Salt
|
129-46-4
|
97.47%
|
|
|
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
|
| T8346 |
SRT 1460
|
925432-73-1
|
97.62%
|
|
|
SRT 1460 is a SIRT1 activator.
|
| T3953 |
Salermide
|
1105698-15-4
|
97.62%
|
|
|
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
|
