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T41248 |
Thiocolchicine
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Microtubule Associated
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Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. |
|
T4435 |
E7820
|
ER68203-00 |
Integrin
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E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells). |
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T27047 |
Clovoxamine
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5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
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|
Clovoxamine fumarate (DU 23811 fumarate) is a 5-hydroxytryptamine reuptake, serotonin and norepinephrine inhibitor with antidepressant and anticonvulsant activity. |
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T62548 |
ATR-IN-17
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ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM). |
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T22490 |
2,3-DCPE hydrochloride
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Others
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Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. |
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T61432 |
ATR-IN-16
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|
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ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1]. |
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T61587 |
ATR-IN-15
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|
|
|
ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cell... |
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T63604 |
ATR-IN-18
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|
|
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ATR-IN-18 is an orally active ATR kinase inhibitor (IC50: 0.69 nM). aTR-IN-18 exhibited anti-proliferative effects in LoVo cells (IC50: 37.34 nM). aTR-IN-18 showed anti-tumor effects. |
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T74771 |
Diaporthein B
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Diaporthein B, a highly oxidized pimarane diterpene, demonstrates significant activity against M. tuberculosis with a MIC of 3.1 μg/mL and exhibits IC50 values ranging from 1.5-3 μM/L against HCT 116 and LoVo colon cance... |
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T78959 |
ATR-IN-23
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|
ATM/ATR
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ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ... |
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T61808 |
ATR-IN-14
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|
|
|
ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, demonstrating a remarkable inhibition rate of 98.03% at 25 nM. Moreover... |
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T63521 |
Bcl-2-IN-7
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Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cell... |
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T63676 |
Bcl-2-IN-6
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|
|
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Bcl-2-IN-6 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2) that downregulates Bcl-2 expression and increases the expression of p53, Bax, and caspase-7 mRNA. bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast... |
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T35897 |
ASK120067
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|
|
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ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]... |
