Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1]. |
In vitro | ATR-IN-23 exhibits significant inhibition of ATR with an IC50 value of 1.5 nM and demonstrates potent antiproliferative activity against LoVo cells, with an IC50 of 0.073 μM [1]. In HT-29 cells, ATR-IN-23 shows moderate antiproliferative efficacy with an IC50 of 0.161 μM [1]. |
In vivo | ATR-IN-23 exhibits acute toxicity at a maximum concentration of 2000 mg/kg, demonstrating moderate safety in ICR mice [1]. When administered at 50 mg/kg either once or twice daily via oral route for 21 days, ATR-IN-23 shows moderate antitumor efficacy in BALB/c nude mice [1]. |
分子量 | 458.56 |
分子式 | C20H22N6O3S2 |
CAS No. | 2923800-62-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ATR-IN-23 2923800-62-6 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR Inhibitor inhibitor inhibit