| TN1673 |
Garcinone C
|
76996-27-5
|
98%
|
|
|
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
|
| T2433 |
NU 7026
|
154447-35-5
|
100%
|
|
|
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition aga...
|
| T63872 |
KU-60019
|
925701-46-8
|
97.15%
|
|
|
KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).
|
| T5175 |
Azd1390
|
2089288-03-7
|
97.47%
|
|
|
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enz...
|
| T19671 |
AZ31
|
2088113-98-6
|
98.01%
|
|
|
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, r...
|
| T1958 |
AZ20
|
1233339-22-4
|
98.02%
|
|
|
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
|
| T62083 |
Camonsertib
|
2417489-10-0
|
98.15%
|
|
|
Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effect...
|
| T3134 |
(Z)-Mirin
|
1198097-97-0
|
98.37%
|
|
|
(Z)-Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
|
| T70873 |
M3541
|
1360628-91-6
|
98.97%
|
|
|
M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by...
|
| T2925 |
Schisandrin B
|
61281-37-6
|
99.02%
|
|
|
Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.
|
| T6770 |
AZD0156
|
1821428-35-6
|
99.13%
|
|
|
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
|
| T2474 |
KU60019
|
925701-49-1
|
99.14%
|
|
|
Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.
|
| T2669 |
Berzosertib
|
1232416-25-9
|
99.19%
|
|
|
Berzosertib (VE-822) has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and A...
|
| T3032 |
VE-821
|
1232410-49-9
|
99.26%
|
|
|
VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).
|
| T1821 |
CGK733
|
905973-89-9
|
99.39%
|
|
|
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
|
| T6100 |
Torin 2
|
1223001-51-1
|
99.47%
|
|
|
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
|
| T2084 |
ETP-46464
|
1345675-02-6
|
99.56%
|
|
|
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
|
| T10406 |
Tuvusertib
|
1613200-51-3
|
99.66%
|
|
|
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activ...
|
| T2235 |
Dactolisib
|
915019-65-7
|
99.71%
|
|
|
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
|
| T4251 |
GJ103 sodium salt
|
1459687-96-7
|
99.75%
|
|
|
GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it eas...
|
