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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T40254	MRTX-1719		Histone Methyltransferase
	MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.		Histone Methyltransferase
T9575	MRTX9768		Histone Methyltransferase
	MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.		Histone Methyltransferase
T76890	Petosemtamab	MCLA 158	EGFR
	Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab...		EGFR
T77007	Fidasimtamab
	Fidasimtamab (IBI-315; BH2950), a recombinant human IgG1 bispecific antibody, specifically targets, binds to, and inhibits HER2 and PD-1 along with their downstream signaling pathways. Additionally, it bridges PD-1 expre...
T36647	Trastuzumab emtansine		Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory deriv...		Others
T125576	Umtatin
	Umtatin is a useful organic compound for research related to life sciences and the catalog number is T125576.
T75029	HEMTAC CDK4/6 degrader 1
	HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests c...
T78760	MTase-IN-1		SARS-CoV
	MTase-IN-1 (compound 26), a potent and selective inhibitor of coronavirus nsp14 N7-methyltransferases, exhibits an IC50 of 0.72 nM. It disrupts viral RNA translation and hinders immune evasion [1].		SARS-CoV
T79873	TNG-462		Histone Methyltransferase
	TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1].		Histone Methyltransferase
T36630	MRTX9768 hydrochloride
	MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT...

Compounds

MRTX-1719

T40254

Synonym:

Target: Histone Methyltransferase

MRTX9768

T9575

Synonym:

Target: Histone Methyltransferase

Trastuzumab emtansine

HEMTAC CDK4/6 degrader 1

Target: Histone Methyltransferase

MRTX9768 hydrochloride

T36630

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T8227	5'-Methylthioadenosine	Methylthioadenosine,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine	Endogenous Metabolite
	5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.		Endogenous Metabolite
T25253	Cinnamtannin B-1	Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358	Antioxidant , COX
	Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant a...		Antioxidant , COX
T82720	Cinnamtannin D2
	Cinnamtannin D2 (compound 13), a tannin derived from Vaccinium vitis-idaea L., boasts isolation from the aforementioned source [1].
T82721	Cinnamtannin B2
	Cinnamtannin B2 (compound 12), a tannin derivative found in cinnamon, has been isolated from the plant Vaccinium vitis-idaea L. [1].
T40977	Cinnamtannin A2
	Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti...

天然物製品

5'-Methylthioadenosine

T8227

Synonym: Methylthioadenosine,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine

Target: Endogenous Metabolite

Cinnamtannin B-1

T25253

Synonym: Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358

Target: Antioxidant, COX

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00567	MTA/SAH nucleosidase Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocy...
TMPH-00692	MTA/SAH nucleosidase Protein, E. coli O9:H4, Recombinant (His & Myc)	E. coli	E. coli
	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocy...
TMPH-03702	MTA/SAH nucleosidase Protein, Vibrio cholerae serotype O1, Recombinant (His & Myc)	Vibrio cholerae	E. coli
	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocy...

MTA/SAH nucleosidase Protein, E. coli, Recombinant (His & Myc)

TMPH-00567

Species: E. coli

Expression System: E. coli

MTA/SAH nucleosidase Protein, E. coli O9:H4, Recombinant (His & Myc)

TMPH-00692

Species: E. coli

Expression System: E. coli

MTA/SAH nucleosidase Protein, Vibrio cholerae serotype O1, Recombinant (His & Myc)

TMPH-03702

Species: Vibrio cholerae

Expression System: E. coli