|
T1176 |
Racecadotril
|
Acetorphan |
Neprilysin
,
Proteasome
|
|
Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis. |
|
T7693 |
Thiorphan
|
|
Neprilysin
|
|
Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM). |
|
TQ0106 |
Sacubitrilat
|
LBQ-657 |
Neprilysin
|
|
Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP). |
|
T4574 |
Sacubitril
|
AHU 377,AHU377,AHU-377 |
Neprilysin
|
|
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. |
|
T4200 |
Sacubitril hemicalcium salt
|
AHU-377 (hemicalcium salt),AHU377 calcium salt |
Neprilysin
|
|
Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug ... |
|
T2318 |
Sacubitril/Valsartan
|
Sacubitril mixture with Valsartan,Valsartan,Sacubitril,LCZ696 |
Apoptosis
,
RAAS
,
Neprilysin
|
|
Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure. |
|
T10918 |
NEP-IN-1
|
|
Neprilysin
|
|
NEP-IN-1 is an inhibitor of neutral endopeptidase (NEP, IC50 = 2 nM) and can be used in studies about female sexual arousal disorders. |
|
T19626 |
LHW090-A7
|
|
Neprilysin
|
|
LHW090-A7 is an neutral endopeptidase (NEP) inhibitor, and an enzyme responsible for the metabolic inactivation of enkephalins. |
|
T27119L |
(Rac)-Daglutril
|
SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid |
Others
|
|
(Rac)-Daglutril (SLV 306 acetic acid) is the racemate form of Daglutril. Daglutril is an orally active, mixed neutral endopeptidase/endothelin converting enzyme inhibitor under development for the treatment of essential ... |
|
TP1917L1 |
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
|
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) |
Bradykinin Receptor
|
|
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cl... |
|
T23698 |
Aladotril
|
BP1137,BP 1137,BP-1137 |
Others
|
|
Aladotril is an inhibitor of neutral endopeptidase. Its prodrug is aladotrilat. |
|
T15696 |
NEP-IN-2
|
|
Others
|
|
NEP-IN-2 is an inhibitor of neutral endopeptidase. It also is used in the research of proliferation in atherosclerosis, restenosis. |
|
T23699 |
Aladotrilat
|
Fasidotrilat |
Others
|
|
Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril. |
|
T28715 |
Sch 34826
|
Sch34826,Sch-34826 |
Others
|
|
Sch 34826 is a potent, selective neutral endopeptidase inhibitor. |
|
T12994 |
SQ28603
|
Squibb 28603,SQ28,603 |
Others
|
|
SQ28603 is a potent and selective neutral endopeptidase 3.4.24.11 (NEP) inhibitor. |
|
T70567 |
CGS 25462
|
|
Others
|
|
CGS 25462 is a neutral endopeptidase (NEP) inhibitor. |
|
T31598 |
Ecadotril
|
S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049 |
Others
|
|
Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role. |
|
T70698 |
MDL-100173
|
|
Others
|
|
MDL-100173 is a dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitor. |
|
T29053 |
UK-447841
|
UK 447841 |
Others
|
|
UK-447841, a neutral endopeptidase (NEP) inhibitor, is used potentially for the treatment of female sexual dysfunction. |
|
T16840 |
Sampatrilat
|
UK-81252 |
Others
|
|
Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). |
|
T26048 |
RB 101
|
RB101,RB-101 |
Others
|
|
RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase. |
|
T30701 |
Candoxatrilat
|
UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578 |
Others
|
|
Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation. |
|
T70471 |
Cgs 26303
|
|
Others
|
|
Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation. |
|
T29052 |
UK-414,495
|
UK 414495,UK414,495,UK414495,UK-414495 |
Others
|
|
UK-414,495 is a potent, selective inhibitor of the neutral endopeptidase, the enzyme normally serves to break down the neuropeptide VIP. |
|
T68601 |
Azidothiorphan
|
|
Others
|
|
Azidothiorphan is a photoaffinity ligand for the active site of the neutral endopeptidase 24.11. After ultraviolet irradiation the inhibitor binds irreversibly to the enzyme, and photolabeling occurs at the active site.... |
|
TP1917 |
Sar-[D-Phe8]-des-Arg9-Bradykinin
|
|
|
|
Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic ac... |
|
T37890 |
GLP-1(28-36)amide
|
|
|
|
GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it ef... |
|
T61095 |
SCH-42354
|
|
Others
|
|
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic pept... |
|
T36943 |
Aminopeptidase N Inhibitor
|
|
Others
|
|
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (... |
|
T76191 |
GLP-1(28-36)amide TFA
|
|
|
|
GLP-1(28-36)amide TFA, a C-terminal nonapeptide derived from GLP-1 cleavage by neutral endopeptidase (NEP), acts as an antioxidant targeting mitochondria. It inhibits mitochondrial permeability transition (MPT), exhibiti... |
|
T81444 |
PL-3994
|
|
|
|
PL-3994, a natriuretic peptide receptor-A (NPR-A) agonist resistant to neutral endopeptidase, functions as a bronchodilator, eliciting a concentration-dependent relaxation of pre-contracted guinea-pig trachea, evidenced ... |
