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T60057 |
Notum pectinacetylesterase-1
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Others
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Notum pectinacetylesterase-1 is a Notum Pectinacetylesterase inhibitor with IC50 < 0.025 μM. |
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T73212 |
Notum-IN-1
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Notum-IN-1 is an orally administered, selective, and brain-penetrating compound that acts as an inhibitor of Notum. It effectively inhibits Wnt signaling in vivo in mice. |
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T38776 |
LP-922056
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Wnt/beta-catenin
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LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively. |
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T77524 |
Carboxylesterase-IN-2
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Wnt/beta-catenin
,
Lipid
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Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases. |
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T23602 |
ABC99
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ABC 99,ABC-99 |
Wnt/beta-catenin
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ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family. |
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T60788 |
Carboxylesterase-IN-3
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Wnt/beta-catenin
,
Lipid
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Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases. |
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T60537 |
ARUK3001185
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ARUK3001185 (Compound 8l) is a potent, selective, orally active, and brain-penetrant Notum inhibitor(IC50 = 6.7 nM) that is suitable for oral dosing in rodent models of disease [1]. |
