Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
説明 | LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively. |
ターゲット&IC50 | Notum Pectinacetylesterase (mouse):55 nM (EC50), Notum Pectinacetylesterase (human):21 nM (EC50) |
In vitro | LP-922056 can be used as a complementary chemical tool for exploring the role of Notum in Wnt signaling[2]. |
In vivo | In mice, LP-922056 (3, 10, 30 mg/kg; gavage) significantly increases midshaft femur cortical bone thickness. LP-922056 (10 mg/kg) achieved high Cmax of 129 μM and AUC of 1533 μM•h while volume of distribution is 0.13 L/kg and low clearance is 0.49 mL/min•kg[1]. LP-922056 (10 mg/kg; oral) increases cortical bone thickness and strength in the midshaft femur, bone mass in the femoral neck, and vertebral body cortical shell[2]. |
分子量 | 300.78 |
分子式 | C11H9ClN2O2S2 |
CAS No. | 1365060-22-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (398.96 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LP-922056 1365060-22-5 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin cortical Pectinacetylesterase thickness orally femur inhibit Wnt lipase bone LP 922056 Notum Inhibitor midshaft LP922056 inhibitor