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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T39516 | Bocidelpar | PPAR | |
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells. | |||
T15567 | Imiglitazar | TAK-559 | PPAR |
Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects. | |||
T15575 | Indeglitazar | PPM 204 | PPAR |
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)). | |||
T4408 | Elafibranor | GFT505 | PPAR |
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively. | |||
T4628 | Seladelpar | MBX 8025 | PPAR |
Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia. | |||
T12528 | Pparδ agonist 1 | Others | |
Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM). | |||
T26182 | Seladelpar lysine | MBX-8025 lysine dihydrate,MBX-8025 Lysine,MBX 8025 Lysine MBX8025 Lysine | Others |
Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH). | |||
T70886 | PT-S58 | Others | |
PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are eff... | |||
T37829 | CAY10573 | Others | |
The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent bindi... | |||
T79454 | Anti-NASH agent 1 | PPAR | |
Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hy... | |||
T35813 | CAY10592 | Others | |
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm... |