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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T12835 Saroglitazar 495399-09-2 98%
Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.
TN1804 Isosilybin A 142796-21-2 98%
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
T9766 GW590735 343321-96-0 98%
GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used...
T22708 Darglitazone 141200-24-0 98%
Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid meta...
T22382 NSC 31150 51244-45-2 98%
NSC 31150 is a potential PPAR agonist with antibacterial, antidiabetic and antioxidant activities and may be used to study cancer and bacterial infections.
TN4583 Moringin 73255-40-0 98%
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T3056 Bavachinin 19879-30-2
Bavachinin (Bavachinin A)(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.
T9808 Tetradecylthioacetic acid 2921-20-2
Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxid...
T7159 L-165041 79558-09-1
L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
T10900 CUDA 479413-68-8
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
TN1525 Convallatoxin 508-75-8
Convallatoxin is a natural product
T39516 Bocidelpar 2095128-20-2
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.
T16074 Mifobate 76541-72-5 100%
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
T11339 Furegrelate sodium 85666-17-7 100%
Furegrelate sodium (U-63557A) is a selective thromboxane synthase inhibitor with oral activity. Furegrelate sodium(U-63557A) inhibits thromboxane A2 (TXA2) synth...
T0448 (S)-(+)-Ibuprofen 51146-56-6 100%
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T3000 Magnolol 528-43-8 100%
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T7821 DG172 dihydrochloride 1361504-77-9 100%
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
T11339L Furegrelate 85666-24-6 100%
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.
T15440 GSK376501A 1010412-80-2 100%
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
T22596 BADGE 1675-54-3 85.3%
PPARγ antagonist
Saroglitazar
T12835
Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.
Isosilybin A
TN1804
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC5...
GW590735
T9766
GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used...
Darglitazone
T22708
Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid meta...
NSC 31150
T22382
NSC 31150 is a potential PPAR agonist with antibacterial, antidiabetic and antioxidant activities and may be used to study cancer and bacterial infections.
Moringin
TN4583
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
Bavachinin
T3056
Bavachinin (Bavachinin A)(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.
Tetradecylthioacetic acid
T9808
Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxid...
L-165041
T7159
L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
CUDA
T10900
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
Convallatoxin
TN1525
Convallatoxin is a natural product
Bocidelpar
T39516
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.
Mifobate
T16074
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
Furegrelate sodium
T11339
Furegrelate sodium (U-63557A) is a selective thromboxane synthase inhibitor with oral activity. Furegrelate sodium(U-63557A) inhibits thromboxane A2 (TXA2) synth...
(S)-(+)-Ibuprofen
T0448
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Magnolol
T3000
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
DG172 dihydrochloride
T7821
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
Furegrelate
T11339L
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.
GSK376501A
T15440
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
BADGE
T22596
PPARγ antagonist
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