|
T39516 |
Bocidelpar
|
|
PPAR
|
|
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells. |
|
T15567 |
Imiglitazar
|
TAK-559 |
PPAR
|
|
Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects. |
|
T4408 |
Elafibranor
|
GFT505 |
PPAR
|
|
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively. |
|
T15575 |
Indeglitazar
|
PPM 204 |
PPAR
|
|
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)). |
|
T4628 |
Seladelpar
|
MBX 8025 |
PPAR
|
|
Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia. |
|
T12528 |
Pparδ agonist 1
|
|
Others
|
|
Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM). |
|
T26182 |
Seladelpar lysine
|
MBX-8025 lysine dihydrate,MBX-8025 Lysine,MBX 8025 Lysine MBX8025 Lysine |
|
|
Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH). |
|
T70886 |
PT-S58
|
|
|
|
PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are eff... |
|
T37829 |
CAY10573
|
|
|
|
The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent bindi... |
|
T79454 |
Anti-NASH agent 1
|
|
PPAR
|
|
Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hy... |
|
T35813 |
CAY10592
|
|
|
|
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm... |
