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T11285 |
FIDAS-5
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Others
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FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities. |
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T11284 |
FIDAS-3
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Others
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Wnt/beta-catenin
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Methionine Adenosyltransferase (MAT)
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FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ... |
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T14141 |
AGI-24512
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Others
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Methionine Adenosyltransferase (MAT)
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AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro. |
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T4676 |
Sardomozide dihydrochloride
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CGP 48664 dihydrochloride,Sardomozide dihydrochloride |
Others
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Sardomozide dihydrochloride (CGP 48664 dihydrochloride) is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC, IC50 = 5 nM). |
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T64377 |
AGI-41998 tautomers
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Others
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AGI-41998 tautomers is a tautomerism of pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-... |
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T12908 |
SIBA
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5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine |
Nucleoside Antimetabolite/Analog
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HSV
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SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as... |
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T26177 |
S-Aristeromycinylhomocysteine
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S-Aristeromycinyl-L-homocysteine |
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S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase. |
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T69891 |
CGP 40215
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CGP 40215 is a specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor that was found to inhibit the growth of Leishmania donovani promastigotes |
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T12833 |
Sardomozide
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CGP 48664,SAM-486A |
Others
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T29651 |
Ademetionine, (S)-
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Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phosphol... |
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T35764 |
S-Farnesyl Thioacetic Acid
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S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can ... |
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T37693 |
N-acetyl-S-geranylgeranyl-L-Cysteine
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N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate f... |
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T35413 |
(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
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(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in... |
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T71162 |
MDL-73811
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MDL-73811 is a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound that cures Brucella infections in mice. However despite the good activity of MDL 73811, rapid plasma clearance... |
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T9730 |
AGI-41998
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AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A) that penetrates the blood-brain barrier.AGI-41998 inhibits s-adenosylmethionine (SAM) metabolizing enzymes and methionine adenosyltransferase 2... |
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T79414 |
SARS-CoV-2-IN-60
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SARS-CoV
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SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and exhibiting an IC50 of 9 µM and a Ki of 26 µM. It binds to a ... |
