Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for MAT2A binding.
説明 | FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for MAT2A binding. |
ターゲット&IC50 | Mat2A:4.9 μM |
In vitro | FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. |
In vivo | FIDAS-3 (20 mg/kg;intraperitoneal injection;daily;for one months;C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors. |
分子量 | 259.29 |
分子式 | C16H15F2N |
CAS No. | 1266684-01-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL(347.10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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FIDAS-3 1266684-01-8 Chromatin/Epigenetic Cytoskeletal Signaling Others Stem Cells Wnt/beta-catenin Methionine Adenosyltransferase (MAT) Inhibitor Wnt CyclinD1 anti-proliferation FIDAS3 c-Myc MAT2A FIDAS 3 β-catenin S-adenosylmethionine anti-cancer SAH inhibit SAM inhibitor