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T12940 |
SMYD3-IN-1
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|
Histone Methyltransferase
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SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM). |
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T73183 |
SMYD3-IN-2
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SMYD3-IN-2, a potent inhibitor of SMYD3, demonstrates significant efficacy in combating gastric cancer by promoting lethal autophagy. It exhibits strong inhibitory activity against both SMYD3 and BGC823 cells, with IC 50... |
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T36631 |
BAY-6035
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MEK
,
Histone Methyltransferase
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BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases. |
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TQ0263 |
EPZ031686
|
EPZ-031686 |
Histone Methyltransferase
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T11486 |
GSK2807 Trifluoroacetate
|
|
Histone Methyltransferase
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GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM). |
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T60777 |
EM127
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|
ERK
,
Histone Methyltransferase
|
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EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional regulation of SMYD3 target genes.EM127 slowly reduces methylt... |
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T5322 |
BCI-121
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Histone Methyltransferase
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BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell. |
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T24038 |
EPZ-030456
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EPZ-030456 is an effective and selective inhibitor of the SMYD3. |
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T69738 |
GSK-2807 free base
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GSK2807 is a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM). GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 may be useful for cancer trea... |
