| T21295 |
BIX02189
|
1265916-41-3
|
98%
|
|
|
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
|
| T21547 |
PAF (C16)
|
74389-68-7
|
98%
|
|
|
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholi...
|
| T5857 |
Trametinib (DMSO solvate)
|
1187431-43-1
|
100%
|
|
|
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)
|
| T2836 |
Isorhamnetin
|
480-19-3
|
92.82%
|
|
|
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorh...
|
| T6785 |
BI-847325
|
1207293-36-4
|
97.13%
|
|
|
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
|
| T2378 |
RGB-286638 free base
|
784210-88-4
|
97.29%
|
|
|
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
|
| T1744 |
BIX02188
|
334949-59-6
|
97.66%
|
|
|
BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
|
| T2708 |
SL327
|
305350-87-2
|
98%
|
|
|
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
|
| T7742 |
GW 284543 hydrochloride
|
179246-08-3
|
98%
|
|
|
GW 284543 hydrochloride is a selective inhibitor of MEK5 .
|
| TMS2181 |
Trans-Zeatin
|
1637-39-4
|
98%
|
|
|
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processin...
|
| T6066 |
SCH772984
|
942183-80-4
|
98.01%
|
|
|
SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.
|
| T2508 |
Binimetinib
|
606143-89-9
|
98.03%
|
|
|
Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay.
|
| T6131 |
Pimasertib
|
1236699-92-5
|
98.15%
|
|
|
Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
|
| T5412 |
RO4987655
|
874101-00-5
|
98.21%
|
|
|
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).
|
| T6971 |
Ro 5126766
|
946128-88-7
|
98.3%
|
|
|
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.
|
| TN1819 |
Kaempferol 3-neohesperidoside
|
32602-81-6
|
98.34%
|
|
|
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, demonstrates an insulinomimetic effect on the rat soleus muscle.
|
| T2327 |
Pelitinib
|
257933-82-7
|
98.37%
|
|
|
Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
|
| T27242 |
EF24
|
342808-40-6
|
98.47%
|
|
|
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of M...
|
| T2623 |
PD98059
|
167869-21-8
|
98.52%
|
|
|
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhi...
|
| T6760 |
APS-2-79 hydrochloride
|
2002381-31-7
|
98.64%
|
|
|
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the co...
|
