|
T6303 |
CCT128930
|
|
Akt
,
PKA
,
S6 Kinase
,
Autophagy
|
|
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. |
|
T6303L |
CCT128930 hydrochloride
|
CCT128930 hydrochloride(885499-61-6 Free base) |
Apoptosis
,
Akt
,
PKA
,
mTOR
,
Autophagy
|
|
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28... |
|
T72726 |
3-epi-Vitamin D3
|
Epicholecalciferol |
|
|
3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in U87MG cells. |
|
T41151 |
K34c
|
|
|
|
K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG ... |
|
T83513 |
(αR)-Cyclopropaneacetamide-Exatecan
|
|
|
|
(αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, serves as a cytotoxic agent that effectively inhibits the proliferation of U87MG and SK-BR-3 cells, exhibiting IC50 values of 8.11 and 2.31 μM... |
|
T63957 |
PI3K-IN-29
|
|
|
|
PI3K-IN-29, a potent inhibitor of PI3K, exhibits substantial inhibition capabilities against U87MG, HeLa, and HL60 cells, with IC50 values of 0.264, 2.04, and 1.14 µM, respectively. It effectively blocks the PI3K/Akt sig... |
|
T70890 |
ML309
|
|
|
|
ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers c... |
|
T83898 |
S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine
|
SFN-Cys,D,L-Sulforaphane-L-cysteine |
|
|
S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agen... |
|
T83911 |
CYY292
|
|
|
|
CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ... |
|
T36035 |
CAY10784
|
|
|
|
CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 ... |
|
T37167 |
Reduced Haloperidol
|
|
|
|
Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4... |
|
T83777 |
LAU-0901
|
|
|
|
LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ... |
|
T35491 |
3,5-dimethyl PIT-1
|
|
|
|
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is impor... |
