T32811 |
L-Leucine-1-13C
|
74292-94-7
|
98%
|
|
L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.
|
T67914 |
Insecticidal agent 364
|
556055-08-4
|
98%
|
|
Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein. Insecticidal agent 364 has antitumor activity, and by inhibiti...
|
T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
T12123 |
MTOR inhibitor-3
|
1207358-59-5
|
98%
|
|
mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.
|
T6346 |
WYE-132
|
1144068-46-1
|
98%
|
|
WYE-125132 (WYE-132 (WYE-125132)) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related...
|
T10413 |
Autogramin-1
|
2375541-73-2
|
98%
|
|
Autogramin-1 potently inhibits autophagy induced by either mTORC1 inhibition (Rapamycin; IC50: 0.44 μM) or starvation (IC50: 0.17 μM).
|
T6159 |
LY-2584702 free base
|
1082949-67-4
|
98%
|
|
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
|
T40351 |
MHY-1685
|
27406-31-1
|
98%
|
|
MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.
|
T12459 |
PI3K/mTOR Inhibitor-2
|
1848242-58-9
|
98%
|
|
PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibi...
|
T36624L |
α-Hydroxyglutaric Acid Lithium
|
|
98%
|
|
α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcyto...
|
T2998 |
Dihydromyricetin
|
27200-12-0
|
|
|
Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase wit...
|
T6033 |
Zotarolimus
|
221877-54-9
|
|
|
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
|
T36083 |
DS-7423
|
1222104-37-1
|
|
|
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].
DS...
|
T4639 |
Azemiglitazone
|
1133819-87-0
|
|
|
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.
|
T7343 |
PF-04979064
|
1220699-06-8
|
|
|
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
|
T1970 |
Gedatolisib
|
1197160-78-3
|
|
|
Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway...
|
T8649 |
TMBIM6 antagonist-1
|
123134-61-2
|
|
|
TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor
|
T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
T3O2749 |
L-Leucine
|
61-90-5
|
100%
|
|
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functi...
|
T5338 |
MTOR inhibitor-1
|
468747-17-3
|
100%
|
|
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
|