|
T12452 |
Digeranyl bisphosphonate
|
DGBP |
Rho
,
Ras
|
|
|
|
T69443 |
Aminobutane bisphosphonate
|
|
|
|
Aminobutane bisphosphonate is a powerful inhibitor of bone resorption. It can potentially be a useful measure for controlling hypercalcemia in patients with carcinoma. |
|
T6739 |
Zoledronic Acid
|
CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa |
Apoptosis
,
Rho
,
Autophagy
|
|
Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc... |
|
T21299 |
Zoledronic acid monohydrate
|
zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate |
Apoptosis
,
Others
,
Autophagy
|
|
Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. |
|
T1599 |
Ibandronic acid
|
Bonviva,Bondronat,Boniva |
Others
,
HBV
|
|
Ibandronic acid (Bonviva) is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities. |
|
T1337 |
Pamidronate Disodium
|
CGP 23339A,CGP 23339AE,Pamidronate disodium salt |
Others
,
HBV
|
|
Pamidronate Disodium (CGP 23339A), a nitrogen-containing bisphosphonate, can help to strengthen bones. |
|
T1599L |
Ibandronate sodium
|
Boniva,Ibandronate sodium salt,Bondronat |
HBV
,
Transferase
|
|
Ibandronate sodium (Boniva) is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis. |
|
T6539 |
Ibandronate sodium monohydrate
|
Boniva monohydrate,Bondronat monohydrate,Ibandronate sodium,BM-210955,BM-21.0955,RPR-102289A |
Apoptosis
,
Others
|
|
Ibandronate sodium monohydrate (BM-210955) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis. |
|
T73506 |
TH-Z93
|
THZ93 |
Antibacterial
|
|
TH-Z93 is a potent FPPS inhibitor (IC50:90 nM) and a lipophilic bisphosphonate. |
|
T6373 |
Alendronate sodium hydrate
|
G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,G-704650 Adronat,Fosamax |
Transferase
|
|
Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis. |
|
T16289 |
NE 10790
|
3-PEHPC |
Others
|
|
NE 10790 (3-PEHPC) is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak anti-resorptive agent. Although NE10790 was a poor inhibitor of FPP synthase |
|
T6451 |
Clodronic acid disodium salt
|
Loron,Clodronate Disodium,Lodronate |
Others
|
|
Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. |
|
T19415 |
Medronic acid
|
Methylenediphosphonic acid |
Others
|
|
Medronic acid (Methylenediphosphonic acid), a methylene-substituted bisphosphonate, exhibits affinity for and adherence to hydroxyapatite crystals within the bone matrix. Accumulating at sites of osteoid mineralization, ... |
|
T14766 |
BPH-715
|
|
Others
,
Parasite
|
|
BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth. With an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells[1]. |
|
T10586L |
BPH-1358
|
NSC50460 |
Others
,
Antibacterial
|
|
BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. a... |
|
T26928 |
BV600022
|
BV-600022,BV 600022 |
|
|
BV600022 is an osteoadsorptive bisphosphonate-ciprofloxacin conjugate with antibacterial activity. |
|
T33873 |
Pamidronate monosodium
|
Pamidronic acid monosodium salt,J710.127I,Pamidronate-monosodium |
|
|
Pamidronate monosodium is a bisphosphonate. |
|
T30836 |
Cgp 47072
|
Cgp-47072,Cgp47072 |
|
|
Cgp 47072 is a bisphosphonate, used in the treatment of bone diseases, particularly where there is uncontrolled bone resorption. |
|
T28151 |
NE21650
|
NE-21650,NE 21650 |
|
|
NE21650, a bisphosphonate, inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. |
|
T11956L |
MBC-11
|
|
Others
|
|
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). It also has the potential to treat tumor-induced bone disease (TIBD). |
|
T61764 |
Zoledronic acid disodium tetrahydrate
|
|
|
|
Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP), exhibiting strong anti-resorptive activity. It effectively inhibits osteoclast differentiation and apoptosis, while al... |
|
T11956 |
MBC-11 triethylamine
|
|
Others
|
|
MBC-11 triethylamine has potential to treat tumor-induced bone disease (TIBD), is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). |
|
T11957 |
MBC-11 trisodium
|
|
Others
|
|
MBC-11 trisodium has potential to treat tumor-induced bone disease (TIBD).It is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. |
|
T39037 |
Tiludronate disodium hemihydrate
|
Tiludronic acid disodium hemihydrate |
|
|
Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a po... |
|
T73056 |
Tiludronate
|
Tiludronic acid |
|
|
Tiludronate (Tiludronic Acid), an orally active bisphosphonate with osteoregulatory activity, is utilized in the study of metabolic bone disorders. It functions as a potent inhibitor of osteoclast vacuolar H(+)-ATPase, s... |
|
T72989 |
HGGPPS-IN-3
|
|
Apoptosis
|
|
Compound 13h (hGGPPS-IN-3) is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS), characterized as a C-2-substituted thienopyrimidine-based bisphosphonate analogue (C2-ThP-BPs). It selectively ind... |
|
T70045 |
HUN47990
|
|
|
|
HUN47990 is a bisphosphonate (BP) prodrug with antitumor activity. HUN47990 potently inhibits the in vitro growth of a variety of tumor cell lines, especially hematopoietic cell lines, at nanomolar concentrations. HUN479... |
|
T10586 |
BPH-1358 free base
|
NSC50460 free base |
Others
|
|
BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng... |
