|
T26519 |
Ablukast
|
Ro 23-3544 |
Leukotriene Receptor
|
|
Ablukast (Ro 23-3544) is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic. |
|
T6397 |
Atracurium besylate
|
Tracrium,51W89,BW-33A |
AChR
|
|
Atracurium besylate (51W89) is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for eliminat... |
|
T1682 |
Methacholine Chloride
|
Mecholyl chloride,Acetyl-β-methylcholine chloride |
AChR
|
|
Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower r... |
|
T3148 |
MK-571 sodium
|
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
|
|
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
|
T67957 |
Pipoxizine
|
|
|
|
Pipoxizine has an antagonistic effect on histamine-induced bronchoconstriction and may be used in the study of asthma disease. |
|
T22787 |
FPL 55712
|
|
LTR
|
|
FPL 55712 is a leukotriene receptor and SRS-A antagonist that inhibits bronchoconstriction and can be used in studies of asthma and coronary artery thrombosis. |
|
T68094 |
Lodoxamide ethyl
|
|
Others
|
|
lodoxamide ethyl is a new orally active anti-allergic compound for the prevention of antigen-induced bronchoconstriction and blockage of skin allergic reactions. |
|
T68090 |
Laprafylline
|
|
Others
|
|
Laprafylline is a xanthine compound with inhibitory effects on bronchoconstriction in vivo and antitumor activity.Laprafylline acts as a competitive serotonergic antagonist at low concentrations, and inhibits constrictio... |
|
T68173 |
ZD-2138
|
Ici-D2138 |
Lipoxygenase
|
|
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolat... |
|
T11388 |
Gemilukast
|
ONO-6950 |
Others
|
|
|
|
T1115 |
Doxylamine succinate
|
Decapryn |
Histamine Receptor
|
|
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... |
|
T71412 |
S 9795
|
|
|
|
S 9795 is a methylxanthine derivative and acts as a potent inhibitor of bronchoconstriction in vivo. |
|
T71541 |
ASP9133
|
|
|
|
ASP9133 is a long-acting muscarinic antagonist (LAMA) which shows more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide. |
|
T26811 |
BI-L 239
|
BIL239,Enofelast,BI-L-239 |
|
|
BI-L 239 is an inhibition of 5-lipoxygenase products that cause bronchoconstriction. |
|
T68723 |
FPL-59257
|
|
|
|
FPL-59257 is a leukotriene antagonist that has been shown to abolish cough response & partly inhibit bronchoconstriction produced by leukotrienes C & D. |
|
TP1999 |
MEN 11270
|
|
|
|
Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other recept... |
|
T21951 |
CDP 840 hydrochloride
|
|
|
|
CDP-840 (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor, which selectively inhibits antigen-induced early and late phase bronchoconstriction in conscious squirrel monkeys [1]. |
|
T28015 |
Mequitamium iodide
|
LG-30435,LG 30435,LG30435 |
|
|
Mequitamium iodide is a platelet activating factor (PAF) inhibitor. Mequitamium inhibits PAF-acether induced platelet aggregation and bronchoconstriction. Mequitamium is capable of inhibiting platelet-mediated effects of... |
|
T36214 |
16,16-dimethyl Prostaglandin E1
|
16,16-dimethyl Prostaglandin E1 |
|
|
16,16-dimethyl Prostaglandin E1 is a PGE1 (T1626) analog that induces bronchoconstriction and vascular smooth muscle contraction and inhibits indomethacin-induced cell elongation. |
|
T38157 |
Ricinelaidic Acid
|
|
|
|
Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neu... |
|
T36770 |
11-deoxy Prostaglandin E1
|
11-deoxy Prostaglandin E1 |
|
|
11-deoxy Prostaglandin E1 is a prostaglandin E1 analogue that has bronchodilator activity and can inhibit histamine-induced bronchoconstriction and cause relaxation of tracheal strips in isolated guinea pigs. |
|
T15415 |
GR 159897
|
|
Others
|
|
GR 159897 is a competitive, brain-penetrated non-peptide NK2 receptor antagonist with anti-tumor effects. GR 159897 inhibits binding of [3H]GR100679 to human NK2-CHO cells and rat colon membranes (pKis: 9.51 and 10, resp... |
|
T70377 |
BAY 61-3606 HCl
|
|
|
|
BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was sh... |
|
T75283 |
Atracurium
|
|
|
|
Atracurium (BW-33A free acid) is a potent, competitive, non-depolarizing neuromuscular blocking agent and an AChR receptor antagonist. It induces bronchoconstriction and neuromuscular blockade, in addition to promoting a... |
|
T37620 |
Leukotriene C4 methyl ester
|
|
|
|
Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met... |
|
T70376 |
CHF-6366
|
|
|
|
CHF-6366 is a dual-action chemical compound acting as a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist, with respective pK i values of 10.4 and 11.4. Additionally, it exhibits weak calcium channel in... |
|
T60332 |
Methacholine bromide
|
|
|
|
Methacholine bromide (Acetyl-β-methylcholine bromide) is a potent muscarinic-3 (M3) agonist that specifically acts on acetylcholine receptors located on smooth muscle, inducing bronchoconstriction and narrowing of the ai... |
|
T71141 |
Fenspiride-d5
|
|
|
|
Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It... |
|
T70456 |
Nolpitantium Free Base
|
|
|
|
Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal s... |
|
T37728 |
Methoctramine (hydrate)
|
|
|
|
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, re... |
|
T38128 |
Leukotriene D4
|
Leukotriene D4 MaxSpec® Standard,LTD4 |
|
|
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4... |
|
T83906 |
Tirzepatide sodium
|
LY3298176 |
|
|
Tirzepatide acts as an agonist for both the glucagon-like peptide 1 receptor (GLP-1R) and G protein-coupled receptor 119 (GPR119), effectively inducing cAMP production in HEK293 cells that express either human GLP-1R or ... |
|
T36618 |
Rupatadine
|
|
|
|
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited ... |
