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Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T16503 PF-4191834 1029317-21-2 98%
PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX ...
TJS0315 4-Methyldaphnetin 2107-77-9 98%
4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl rad...
T6S1699 Shogaol 555-66-8 98%
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory prop...
T1420 Diethylcarbamazine citrate 1642-54-2 98%
Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria banc...
TN2068 Picrinine 4684-32-6 98%
Picrinine is an akuammiline alkaloid extracted from the leaves of Alstonia scholaris. It exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase.
T3399 Psoralidin 18642-23-4 98%
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
TN1308 6-Hydroxyflavanone 4250-77-5 98%
6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
TQ0180 Chebulagic acid 23094-71-5 98%
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
T6243 U-73122 112648-68-7 98%
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
T39986 LOX-IN-3 dihydrochloride 2409964-23-2 98%
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities...
TN1016 Kukoamine A 75288-96-9 98%
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T60438L PXS-6302 hydrochloride 2584947-79-3 98%
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3....
T77677 12R-LOX-IN-2 98%
12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibi...
TN2330 Phenethyl ferulate 71835-85-3 98%
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis ...
T17191 Bunaprolast 99107-52-5 98%
Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and TXB2...
T6576 Malotilate 59937-28-9 98%
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
T1677 Montelukast 158966-92-8 100%
Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has be...
T67908 ThioLox 1202193-89-2 100%
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has ...
T34624 Setileuton 910656-27-8 100%
Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
T68173 ZD-2138 140841-32-3 100%
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-...
PF-4191834
T16503
PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX ...
4-Methyldaphnetin
TJS0315
4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl rad...
Shogaol
T6S1699
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory prop...
Diethylcarbamazine citrate
T1420
Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria banc...
Picrinine
TN2068
Picrinine is an akuammiline alkaloid extracted from the leaves of Alstonia scholaris. It exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase.
Psoralidin
T3399
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
6-Hydroxyflavanone
TN1308
6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
Chebulagic acid
TQ0180
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
U-73122
T6243
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
LOX-IN-3 dihydrochloride
T39986
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities...
Kukoamine A
TN1016
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
PXS-6302 hydrochloride
T60438L
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3....
12R-LOX-IN-2
T77677
12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibi...
Phenethyl ferulate
TN2330
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis ...
Bunaprolast
T17191
Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and TXB2...
Malotilate
T6576
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
Montelukast
T1677
Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has be...
ThioLox
T67908
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has ...
Setileuton
T34624
Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
ZD-2138
T68173
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-...
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