|
T1520 |
Aliskiren hemifumarate
|
CGP 60536,SPP 100,CGP60536B |
RAAS
,
Autophagy
|
|
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. |
|
T69526 |
PF-07258669
|
|
Melanocortin Receptor
|
|
PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite. |
|
T76774 |
Ponsegromab
|
PF 06946860 |
TGF-beta/Smad
|
|
Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor. Ponsegromab has anti-cachexic activity by binding to GDF15 to prevent its binding to GFRAL, thus disrupting GDF15/GFRAL medi... |
|
T2408 |
Ostarine
|
MK-2866,GTX-024,Enobosarm |
Androgen Receptor
|
|
Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostat... |
|
T27986 |
MCL0129
|
MCL-0129,MCL 0129 |
|
|
MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia. |
|
T80541 |
TCMCB07 TFA
|
|
Melanocortin Receptor
|
|
TCMCB07 TFA is a cyclic nonapeptide and an orally active, brain-penetrating antagonist of the melanocortin receptor 4 (MC4R), playing a significant role in managing cachexia [1]. |
|
T64163 |
Aliskiren hydrochloride
|
|
|
|
Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is a selective, orally active, renin inhibitor (IC50: 1.5 nM). Cachexia. |
|
T82263 |
GPR61 Inverse agonist 1
|
|
|
|
Compound 1, identified as a GPR61 inverse agonist, exhibits an IC50 of 11 nM, rendering it suitable for metabolism and body weight disorder research, including obesity and cachexia [1]. |
|
T80540 |
TCMCB07
|
|
Melanocortin Receptor
|
|
TCMCB07, a cyclic nonapeptide, serves as an orally active, brain-penetrant antagonist of the melanocortin receptor 4 (MC4R), with significant implications in the management of cachexia [1]. |
|
T72526 |
Aliskiren fumarate
|
CGP 60536 fumarate,SPP 100 fumarate,CGP 60536 fumarate ; CGP60536B fumarate ; SPP 100 fumarate,CGP60536B fumarate |
|
|
Aliskiren fumarate, an orally active, highly potent, and selective renin inhibitor with an IC50 of 1.5 nM, is utilized in the research of hypertension, cardiovascular diseases, and cancer cachexia. |
|
T68276 |
Macimorelin acetate
|
EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate |
|
|
Macimorelin Acetate (EP-1572), an orally active growth hormone (GH) secretagogue and a ghrelin receptor (GHSR) agonist, stimulates GH release. It is utilized in research focusing on adult growth hormone deficiency (AGHD)... |
|
T39236 |
Relamorelin acetate
|
Relamorelin acetate,RM-131 acetate,BIM-28131acetate |
|
|
Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki v... |
|
T75262 |
Relamorelin TFA
|
|
|
|
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, acts as a potent and selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR), with a K_i of 0.42 nM for the GHS-1a receptor. This compound is... |
