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カタログ番号 | 製品名 | 別名 | ターゲット |
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T14004 | 1A-116 | Rho | |
1A-116 is a specific inhibitor of Rac1 . | |||
T9608 | KL201 | Others | |
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. | |||
T22891 | KL001 | KL 001,KL-001 | Others |
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced glu... | |||
TP1264 | Prolylleucine | ((Benzyloxy)carbonyl)-L-prolyl-D-leucine | Others |
Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) is a dipeptide containing branched-chain amino acids. | |||
T9356 | (E/Z)-GO289 | Casein Kinase | |
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function... | |||
T3495 | Tasimelteon | VEC-162,BMS-214778 | Melatonin Receptor , MT Receptor |
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. | |||
T27931 | LY2033298 | LY 2033298,LY-2033298 | AChR |
LY2033298, a positive allosteric modulator of muscarine M4 receptor, enhances the inhibitory effect of oximoline on light-induced phase shift in circadian activity in hamsters and can be used in neurosystem-related disea... | |||
T73573 | CLK8 | Others | |
CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-... | |||
T3685 | SR9009 | Stenabolic,REV-ERB Agonist II | Autophagy |
SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during... | |||
T63375 | FT709 | ||
FT709 is a selective and potent inhibitor of USP9X (IC50: 82 nM). Among others, USP9X is associated with centrosome function, EGF receptor degradation, chromosome alignment during mitosis, chemosensitization and circadia... | |||
T27430 | GR 196429 | GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 | |
GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice. | |||
T70812 | PF-05236216 hydrochloride | ||
PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice. | |||
T32401 | KL044 | KL 044,KL-044 | Others |
KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway. | |||
T82587 | Delta (Phospho) Sleep Inducing Peptide | DSIP-P | |
Delta (Phospho) Sleep Inducing Peptide (DSIP-P), a peptide that promotes sustained sleep, elicits alterations in circadian locomotor activity in rats [1] [2] [3]. | |||
T80849 | VU661 | ||
VU661, a redox-active phenazine carboxamide, modulates circadian rhythms by inducing period lengthening. | |||
T17095 | TIK-301 | PD-6735,LY-156735 | 5-HT Receptor |
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an... | |||
TP1980 | Neuromedin S(rat) | Neuromedin S (rat) | |
Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent en... | |||
T38433 | KS15 | ||
KS15 is a chemical compound that acts as an inhibitor on the interactions between cryptochromes, specifically CRY1 and CRY2, and the CLOCK: BMAL1 heterodimer. This compound, with an EC50 value of 4.9 μM, hinders the feed... | |||
TP2194 | Neuropeptide Y (scrambled) | Others | |
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiologi... | |||
T35993 | Epitalon (acetate) | ||
Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalo... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN1162 | Dibutyl phthalate | 1,2-Benzenedicarboxylic acid | Antifection |
Dibutyl phthalate (1,2-Benzenedicarboxylic acid) is a plasticizer widely used in industrial manufacturing.Dibutyl phthalate modulates MSH6 crotonylation, induces induced oxidative damage and genotoxicity, and disrupts co... | |||
T71896 | Brevicompanine B | ||
Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various gen... | |||
TN1812 | Jujuboside B1 | 5-HT Receptor | |
Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides may be good source of lead compounds for n... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-00079 | Beta-amylase 3, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | E. coli |
Beta-amylase activity. No alpha-amylase activity. Involved in cold resistance. Mediates the accumulation of maltose upon freezing stress, thus contributing to the protection of the photosynthetic electron transport chain... | |||
TMPH-01241 | TOP1 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran... | |||
TMPH-03711 | PPAR gamma Protein, Xenopus laevis, Recombinant (His) | Xenopus laevis | E. coli |
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcript... | |||
TMPY-01120 | VPAC2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
VIP and PACAP receptor 2, or VIPR2 encodes the VPAC2 receptor, which binds both VIP and PACAP. VPAC2 is expressed throughout the central nervous system and the periphery. Mutations in the VIPR2 homolog in the mouse cause... | |||
TMPY-00286 | Neuropeptide Y Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress ... | |||
TMPJ-01112 | PRKG1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro... | |||
TMPH-02574 | P53 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-02855 | PML Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and vi... | |||
TMPH-03264 | P53 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... |