Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
説明 | KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes. |
別名 | KL 001, KL-001 |
分子量 | 398.48 |
分子式 | C21H22N2O4S |
CAS No. | 309928-48-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (163.12 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KL001 309928-48-1 Others Inhibitor KL 001 inhibit stabilizer KL-001 circadian cryptochrome ubiquitin period gluconeogenesis CRY inhibitor