検索結果

Search Results for " colonic "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T0081	Lafutidine	FRG-8813	5-HT Receptor , Histamine Receptor
	Lafutidine (FRG-8813) is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.		5-HT Receptor , Histamine Receptor
T13385	Zamifenacin fumarate	UK-76654 fumarate	AChR
	Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.		AChR
T0918	Trimebutine	Mebutin	Opioid Receptor
	Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl...		Opioid Receptor
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...
T30640	Butyrylcholine	BA 51 090059,BA-51-090059,BA 51090059,BA 51-090059
	Butyrylcholine is a novel colonic ion transport regulator produced by colonic epithelial cells that stimulates nicotine and muscarinic receptors.
T34710	STA 2	ONO 11113,STA-2,STA2
	STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium.
T29887	Aloe emodin anthrone
	Aloe emodin anthrone is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
T33443	MK-8970
	MK-8970 is an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.
T71738	DRAinh-A250
	DRAinh-A250 is a SLC26A3 inhibitor which blocks colonic fluid absorption and reduces constipation.
T17283	Zamifenacin	UK-76654	Others
	Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist.		Others
T35374L	(Ala13)-Apelin-13 acetate		Apelin receptor
	(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.		Apelin receptor
T68735	Ciclotropium (free base)
	Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing...
T35708	N-acetyl-5-Aminosalicylic Acid
	N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-ac...
T76319	Urocortin III (mouse) (free acid)
	Urocortin III (mouse) (free acid), a selective agonist with high affinity for the CRF2 receptor, significantly inhibits gastric emptying while not affecting colonic transit [1] [2].
T64294	Succinic acid sodium
	Succinic acid sodium is an orally active anxiolytic. Succinic acid sodium down-regulates the expression of KCNMB1 (potassium channel subunit β1) and TET1 (10-11 translocation 1). succinic acid sodium inhibits the prolife...
T78540	α-CGRP (mouse, rat) TFA		CGRP Receptor
	α-CGRP (mouse, rat) TFA, a neuropeptide belonging to the calcitonin gene-related peptide (CGRP) family, is predominantly located at neuromuscular junctions and functions as a potent vasodilator. Peripheral administration...		CGRP Receptor
T83955	MOMBA
	MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate...
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II...
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ...

Compounds

Lafutidine

T0081

Synonym: FRG-8813

Target: 5-HT Receptor, Histamine Receptor

Zamifenacin fumarate

T13385

Synonym: UK-76654 fumarate

Target: Opioid Receptor

Synonym: BA 51 090059,BA-51-090059,BA 51090059,BA 51-090059

Target:

STA 2

T34710

Synonym: ONO 11113,STA-2,STA2

(Ala13)-Apelin-13 acetate

T35374L

Synonym:

Target: Apelin receptor

Ciclotropium (free base)

T68735

Synonym:

Target:

N-acetyl-5-Aminosalicylic Acid

T35708

Synonym:

Target:

Urocortin III (mouse) (free acid)

α-CGRP (mouse, rat) TFA

T78540

Synonym:

Target: CGRP Receptor

Urocortin II (mouse) (trifluoroacetate salt)

T36373

Synonym:

Target:

(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

T65994

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T4S0554	Theaflavine-3,3'-digallate	TFBG,theaflavin digallate	Others
	1. Theaflavine-3,3'-digallate (theaflavin digallate) and lactic acid together could reduce herpes simplex virus transmission.		Others
T5254	Glycodeoxycholate Sodium	Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt	Others , Endogenous Metabolite
	Glycodeoxycholate Sodium (Glycodeoxycholic acid sodium salt) induces Apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes ex...		Others , Endogenous Metabolite
T5259	Glycochenodeoxycholic acid sodium salt	GCDCA,Sodium glycochenodeoxycholate	Apoptosis , Others , Endogenous Metabolite
	Glycochenodeoxycholic acid sodium salt (GCDCA) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environmen...		Apoptosis , Others , Endogenous Metabolite
T5234	Glycoursodeoxycholic acid	Ursodeoxycholylglycine,GUDCA	Others , Endogenous Metabolite
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic enviro...		Others , Endogenous Metabolite
T29888	Aloe-emodin-glucoside
	Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
TN1834	Kobusin		Others , NOS , NF-κB
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...		Others , NOS , NF-κB
T37770	Taurohyodeoxycholic acid
	Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol ...

天然物製品

Theaflavine-3,3'-digallate

T4S0554

Synonym: TFBG,theaflavin digallate

Target: Others

Glycodeoxycholate Sodium

T5254

Synonym: Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt

Target: Others, Endogenous Metabolite

Glycochenodeoxycholic acid sodium salt

T5259

Synonym: GCDCA,Sodium glycochenodeoxycholate

Target: Apoptosis, Others, Endogenous Metabolite

Glycoursodeoxycholic acid

T5234

Synonym: Ursodeoxycholylglycine,GUDCA

Target: Others, Endogenous Metabolite

Aloe-emodin-glucoside

Target: Others, NOS, NF-κB

Taurohyodeoxycholic acid

T37770

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00539	GSTA1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) ...
TMPH-02823	Peptide YY/PYY Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
TMPH-01852	Peptide YY/PYY Protein, Human, Recombinant (GST)	Human	E. coli
	This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Peptide YY/PYY Protein, Human, Recombinant (GST) is expressed in E. coli expression syste...
TMPH-03266	CHI3L1 Protein, Rat, Recombinant (His)	Rat	E. coli
	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a rol...
TMPK-01137	FAM3D Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (m...
TMPJ-01155	PDCD4 Protein, Human, Recombinant (His)	Human	E. coli
	Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation...
TMPY-03329	DPEP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl...
TMPY-04207	Motilin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal c...
TMPJ-01199	BTN2A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two i...
TMPY-03308	ADAM17 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative coliti...
TMPY-00493	IL-19 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the r...
TMPJ-00698	BTNL2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Butyrophilin-like 2 (BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation. Mouse BTNL2 is type I transmembrane glycoprotein that contains an extracellular domai...
TMPY-01000	BVES Protein, Human, Recombinant (GST)	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protecti...