NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	製品名	CAS No.	Purity
TN1923	Mesaconine	6792-09-2	98%
TN1923	Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material bas...
T1934	Bay 11-7085	196309-76-9	98%
T1934	Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
TN2079	(-)-Pinoresinol	81446-29-9	98%
TN2079	(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
T39924	NF-κΒ activator 2	2375281-44-8	98%
T39924	NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activatio...
TN6963	Hentriacontane	630-04-6	98%
TN6963	Hentriacontane is a natural product.
TN7235	4-methoxylonchocarpin	51589-67-4	98%
TN7235	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TN...
TN1493	Chrysosplenol D	14965-20-9	98%
TN1493	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN1067	Galloylpaeoniflorin	122965-41-7	98%
TN1067	Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibti...
TN2546	1-Isomangostin	19275-44-6	98%
TN2546	1-Isomangostin has cytotoxic and anticomplementary activities.
TN1143	1-O-Acetyl britannilactone	681457-46-5	98%
TN1143	1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
TWS1977	Kamebakaurin	73981-34-7	98%
TWS1977	1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response an...
TN3209	3′,4′,7-Trihydroxyflavone	2150-11-0	98%
TN3209	3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
T16974	TAK-243	1450833-55-2	98%
T16974	TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signa...
TQ0305	CID-2858522	758679-97-9	98%
TQ0305	CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
T6454	CORM-3	475473-26-8
T6454	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
TN1141	Isodeoxyelephantopin	38927-54-7
TN1141	Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
T6661	SC75741	913822-46-5
T6661	SC75741 is a potent P65 inhibitor with IC50 of 200 nM
T2893	Muscone	541-91-3
T2893	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T2830	Betulinic acid	472-15-1
T2830	Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...