NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	製品名	CAS No.	Purity
TN1923	Mesaconine	6792-09-2	98%
TN1923	Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material bas...
T1144	Lidocaine hydrochloride	73-78-9	98%
T1144	Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
T0694	Pranlukast	103177-37-3	98%
T0694	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T0607	Dihydroartemisinin	71939-50-9	98%
T0607	Dihydroartemisinin is a metabolite of artemisinin.
T0429	Glucosamine	3416-24-8	98%
T0429	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T4S1881	Aconine	509-20-6	98%
T4S1881	1. Aconine is the febrifuge. 2. Aconine possesses gastric anaesthetic props.
T1229	Erdosteine	84611-23-4	98%
T1229	Erdosteine is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus produc...
TN1466	Canthin-6-one	479-43-6	98%
TN1466	Canthin-6-one has antimicrobial, cytotoxic, antiproliferative and proapoptotic effects, possibly by interfering with the G2/M transition; it also has antiinflamm...
TN1141	Isodeoxyelephantopin	38927-54-7	98%
TN1141	Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
T6661	SC75741	913822-46-5	98%
T6661	SC75741 is a potent P65 inhibitor with IC50 of 200 nM
T3147	Pyrrolidinedithiocarbamate ammonium	5108-96-3	98%
T3147	Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
TN1660	Ganoderic acid C1	95311-97-0	98%
TN1660	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T0304	Methylthiouracil	56-04-2	98%
T0304	Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T0907	Sulfasalazine	599-79-1	98%
T0907	Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T2759	Loganin	18524-94-2	98%
T2759	Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent ...
T4S2063	Tetrahydrocoptisine	4312-32-7	98%
T4S2063	1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
T3816	Velutin	25739-41-7	98%
T3816	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as ...
T0122	Bergenin	477-90-7	98%
T0122	Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T2921	Sinomenine hydrochloride	6080-33-7	98%
T2921	Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.