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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TN1923 Mesaconine 6792-09-2 98%
Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material bas...
T2S1040 Jolkinolide B 37905-08-1 98%
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
TN1094 Ginsenoside Rg6 147419-93-0 98%
Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an incr...
TN2079 (-)-Pinoresinol 81446-29-9 98%
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
T39924 NF-κΒ activator 2 2375281-44-8 98%
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activatio...
TN6963 Hentriacontane 630-04-6 98%
Hentriacontane is a natural product.
TN7235 4-methoxylonchocarpin 51589-67-4 98%
4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TN...
TN1067 Galloylpaeoniflorin 122965-41-7 98%
Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibti...
TN2546 1-Isomangostin 19275-44-6 98%
1-Isomangostin has cytotoxic and anticomplementary activities.
TWS1977 Kamebakaurin 73981-34-7 98%
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response an...
TN1376 α-Solanine 20562-02-1 98%
α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB path...
TN3209 3′,4′,7-Trihydroxyflavone  2150-11-0 98%
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
T84309 MAO-B-IN-30 82973-15-7 98%
MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-...
T78082 Supercinnamaldehyde 70351-51-8 98%
Supercinnamaldehyde is a transient receptor potential anchor protein 1 (TRPA1) activator with thousands of anticancer and antimicrobial activities.Supercinnamald...
T16974 TAK-243 1450833-55-2 98%
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signa...
TQ0305 CID-2858522 758679-97-9 98%
CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
T6454 CORM-3 475473-26-8
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
T6661 SC75741 913822-46-5
SC75741 is a potent P65 inhibitor with IC50 of 200 nM
T2893 Muscone 541-91-3
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T2830 Betulinic acid 472-15-1
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
Mesaconine
TN1923
Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material bas...
Jolkinolide B
T2S1040
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
Ginsenoside Rg6
TN1094
Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an incr...
(-)-Pinoresinol
TN2079
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
NF-κΒ activator 2
T39924
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activatio...
Hentriacontane
TN6963
Hentriacontane is a natural product.
4-methoxylonchocarpin
TN7235
4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TN...
Galloylpaeoniflorin
TN1067
Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibti...
1-Isomangostin
TN2546
1-Isomangostin has cytotoxic and anticomplementary activities.
Kamebakaurin
TWS1977
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response an...
α-Solanine
TN1376
α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB path...
3′,4′,7-Trihydroxyflavone 
TN3209
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
MAO-B-IN-30
T84309
MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-...
Supercinnamaldehyde
T78082
Supercinnamaldehyde is a transient receptor potential anchor protein 1 (TRPA1) activator with thousands of anticancer and antimicrobial activities.Supercinnamald...
TAK-243
T16974
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signa...
CID-2858522
TQ0305
CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).
CORM-3
T6454
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
SC75741
T6661
SC75741 is a potent P65 inhibitor with IC50 of 200 nM
Muscone
T2893
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
Betulinic acid
T2830
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
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