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T4385 |
PF-4840154
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TRP/TRPV Channel
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PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. |
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T8483 |
Cysteine thiol probe
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Methyl (4-bromobenzoyl)-L-cysteinate |
Others
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Cysteine thiol probe (Methyl (4-bromobenzoyl)-L-cysteinate) is a chemoselective thiol probe for detection of electrophilic metabolites |
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T9432 |
6-Bromo-2-naphthol
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Others
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6-Bromo-2-naphthol is an electrophilic carbene intermediate. |
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T31413 |
DiaAlk
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DiaAlk is a clickable, electrophilic diazene probe which enables capture and site-centric proteomic analysis of oxidative post-translational modification (OxiPTM). |
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T73542 |
DB008
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DB008, a potent and selective PARP16 inhibitor, exhibits an IC50 value of 0.27 μM, incorporating an acrylamide electrophilic reagent. This membrane-permeable compound specifically targets PARP16. |
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T78949 |
AM841
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Cannabinoid Receptor
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AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi... |
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T81776 |
MN551
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MN551 is a potent inhibitor that targets the cysteine-directed electrophilic covalent activity essential for the function of SOCS2 within its CRL5 complex. This compound also acts as an E3 ligase mediator, facilitating P... |
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T78158 |
MitoCur-1
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Others
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MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compoun... |
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TNU0658 |
2-bromomethyl benzothizaole
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2-bromomethyl benzothizaole is a derivative of benzothiazole. It is an intermediate and building block electrophilic reagent that has been used in the synthesis of many compounds such as 2-bromo-4-methyl-1,3-benzothiazol... |
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T36614 |
DL-Sulforaphane N-acetyl-L-cysteine
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Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressor... |
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T37594 |
Pericosine A
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Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lin... |
