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T9889 |
M4 mAChR agonist-1
|
4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)- |
AChR
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M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM). |
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T81893 |
M1/M4 muscarinic agonist 2
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|
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Compound 40 is a selective M1/M4 muscarinic antagonist with an IC50 of 19 nM for M1 receptors and 42 nM for M4 receptors [1]. |
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T4494 |
CLOZAPINE N-OXIDE
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|
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Drug Metabolite
|
|
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa... |
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T23297 |
(S)-(+)-Dimethindene maleate
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|
AChR
,
Histamine Receptor
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(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that inhibits muscarinic M1, M3, and M4 receptors. |
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T6575 |
LY2119620
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|
AChR
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LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. |
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T17244 |
VU0467154
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|
AChR
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VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively. |
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T9694 |
Emraclidine
|
CVL-231 |
AChR
|
|
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies. |
|
T8219 |
VU0238441
|
|
AChR
|
|
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. |
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T0862 |
Diphenidol hydrochloride
|
Diphenidol HCl,Difenidol hydrochloride |
Sodium Channel
,
AChR
|
|
Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug. |
|
T1475 |
Fesoterodine fumarate
|
Toviaz,SPM 907 |
AChR
|
|
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |
|
T1281 |
Tropicamide
|
Ro 1-7683 |
AChR
|
|
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... |
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T23124 |
PD 102807
|
|
Others
|
|
M4 muscarinic receptor antagonist |
|
T13924 |
Thiochrome
|
|
Others
|
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Thiochrome is a selective enhancer of M4 muscarinic receptor of acetylcholine (ACh) affinity. |
|
T39543 |
VU6000918
|
|
|
|
VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor. |
|
T17245 |
VU0467485
|
AZ13713945 |
Others
|
|
VU0467485 is a potent and selective muscarinic acetylcholine receptor 4 positive allosteric modulator. VU0467485 potentiates the activity of ACh at M4 (EC50s: 26.6 nM and 78.8 nM at the rat and human M4 receptors, respec... |
|
T39010 |
Xanomeline tartrate
|
LY 246708 tartrate,Xanomeline tartrate |
|
|
Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia. |
|
T13322 |
VU6005806
|
AZN-00016130 |
Others
|
|
VU6005806 is a potent positive allosteric modulator (PAM) of muscarinic acetylcholine receptor subtype 4 (M4) (EC50s: 94 nM, 28 nM, 87 nM, and 68 nM for human, rat, dog, and cyno M4, respectively), and used in the study ... |
|
T36662 |
Imidafenacin Metabolite M4
|
Imidafenacin Metabolite M4 |
|
|
Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4.
1.Kanayama, N., Kanari, C., Masuda,... |
|
T23763 |
Atropine Oxide
|
NSC 72861,NSC72861,NSC-72861 |
|
|
Atropine Oxide is a derivative of Atropine. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5. Atropine is a medication to treat certain types of nerve agents and ... |
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T16443 |
PCS1055 dihydrochloride
|
|
Others
|
|
|
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T39545 |
MK-6884
|
|
|
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MK-6884, a positive allosteric modulator (PAM) of M4 muscarinic receptors, exhibits a high affinity (Ki = 0.19 nM). It is a valuable compound for the investigation of neurodegenerative diseases. Additionally, MK-6884 can... |
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T37728 |
Methoctramine (hydrate)
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|
|
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Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, re... |
|
T80477 |
Muscarinic toxin 3
|
MT3 |
Adrenergic Receptor
|
|
Muscarinic toxin 3 (MT3), a potent non-competitive antagonist of mAChR and adrenoceptors, exhibits pIC50 values of 6.71 for M1, 8.79 for M4, 8.86 for α1A, 7.57 for α1B, 8.13 for α1D, 8.49 for α2A, <6.5 for α2B, and 7.29 ... |
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T69232 |
Atropine Oxide Hydrochloride
|
|
|
|
Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surger... |
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T74709 |
LAS190792
|
|
|
|
LAS190792 (AZD8999) is a dual-action chemical compound that simultaneously acts as a strong muscarinic antagonist and β2-adrenoceptor agonist. It exhibits significant potency across a range of receptors, with pIC50 value... |
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T71963 |
(−)-WIN 55,212-3 mesylate
|
|
|
|
(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism ... |
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T36241 |
Arecaidine propargyl ester (hydrobromide)
|
|
|
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Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0... |
