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T13664 |
DSP-4 hydrochloride
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Neurotoxin DSP 4 (hydrochloride) |
Others
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DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) (Neurotoxin DSP 4 hydrochloride) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus... |
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T12214 |
Neurotoxin Inhibitor
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Others
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Neurotoxin Inhibitor is an inhibitor of neurotoxin. |
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T4081 |
MPTP hydrochloride
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MPTP-hydrochloride |
Apoptosis
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Dopamine Receptor
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MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th... |
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T27794 |
λ-Cyhalothrin
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lambda-Cyhalothrin,Karate,Icon |
Sodium Channel
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Parasite
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λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pes... |
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T9354 |
2,4-Difluorobenzaldehyde
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2,4-Difluoro-benzaldehyde |
Others
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2,4-Difluorobenzaldehyde target bont - botulinum neurotoxin type A (Clostridium botulinum) |
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T28655 |
Sabeluzole
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R 58735,R58735,R-58735 |
Microtubule Associated
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Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.Sabeluzole is protective against chlordiazepoxide-induced habituation disorders and may be... |
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TP1223L |
Apamin acetate
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Apamine acetate,Apamin acetate(24345-16-2 Free base) |
Potassium Channel
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Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following lacera... |
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T9169 |
MPP+ iodide
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Mitochondrial Metabolism
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Autophagy
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MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex... |
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T32850 |
Lolitrem A
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Lolitrem A is a neurotoxin from staggers-producing ryegrass pastures. |
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T33644 |
Nephilatoxin 7
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NPTX 7,NPTX7,NPTX-7 |
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Nephilatoxin 7 is a neurotoxin of the Joro spider (Nephila clavata). |
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T13819 |
Pi-Methylimidazoleacetic acid hydrochloride
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Others
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Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin. |
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T34794 |
Tecoram
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Tecoram is a dithiocarbamate and a possible neurotoxin. |
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T26937 |
C562-1101
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C562-1101 is a novel potent botulinum neurotoxin serotype E (BoNT/E) inhibitor. |
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T25890 |
NSC-84096
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CID 256758,CID-256758,CID256758 |
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NSC-84096 is an endopeptidase activity inhibitor of botulinum neurotoxin type A light chain (rBoNT/A-LC). |
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T33346 |
Methylaminoalanine-nickel(II)
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L-Bmma-nickel(II),L-Medap-nickel(II) |
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Methylaminoalanine-nickel(II) can be regarded as a naturally occurring neurotoxin. |
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T69377 |
BoNT-IN-33
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BoNT-IN-33 is a potent inhibitor of Botulinum neurotoxin/A light chain (BoNT/A LC). |
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T14763 |
BoNT-IN-1
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Others
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BoNT-IN-1 is a potent Botulinum neurotoxin A light chain (BoNTA LC) inhibitor(IC50 : 0.9 uM). |
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TP2064 |
ω-Conotoxin MVIIC
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Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels. |
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T26961 |
CBIP
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CBIP is a small-molecule inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC). CBIP possesses low micromolar activity against BoNT/A. |
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T21464 |
Methiocarb
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Mercaptodimethur,Mesurol |
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Methiocarb, a carbamate pesticide, is used as an insecticide, acaricide, bird repellent, and molluscicide. Methiocarb stimulates cholinergic by inhibiting reversibly acetylcholinesterase activity, making methiocarb a pot... |
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T31582 |
DSP 4
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DSP4,UNII-PQ1P7JP5C1,DSP-4,az-Dsp 4 |
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DSP 4 is a selective neurotoxin selective for noradrenergic neurons in the locus coeruleus noradrenergic system and capable of crossing the blood–brain barrier and cyclizes to a reactive aziridinium derivative that is ac... |
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TP2062 |
ω-Conotoxin GVIA
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Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo. |
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TP1576 |
SNAP-25 187-203
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This amino acids187 to 203 fragment is derived from the C-terminal helix of synaptosomal-associated protein of 25 kDa (SNAP-25). This peptide is able to rescue exocytosis from botulinum neurotoxin E (BoNT/E)-treated cell... |
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TP2077 |
α-Bungarotoxin
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Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β... |
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T80160 |
ω-Hexatoxin-Hv1a
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ω-ACTX-Hv1,ω-Atracotoxin-HV1 |
Calcium Channel
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ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium channels [1] [2]. |
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T80078 |
Calciseptin
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Calcium Channel
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Calciseptine, a neurotoxin isolated from the Black Mamba (Dendroaspis p. polylepis) venom, comprises 60 amino acids and is stabilized by four disulfide bonds. It specifically targets and blocks L-type calcium channels [1... |
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TP2016 |
Huwentoxin-IV
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Huwentoxin IV |
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Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel b... |
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T83223 |
AaHI
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AaHI, a neurotoxin sourced from the venom of the North African scorpion Androctonus australis hector, serves as a research tool for creating agents with the ability to neutralize toxins [1]. |
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T80454 |
BmK-M1
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Sodium Channel
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BmK-M1, a scorpion-derived toxin, consists of a 64-amino acid polypeptide stabilized by four disulfide bridges. This compound functions as an inhibitor of the Na+ channel, classifying it as both a cardiotoxin and a neuro... |
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T80064 |
Dendrotoxin-I
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DTX-I |
Potassium Channel
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Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 and KV1.2 [1] [2] [3]. |
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TP1223 |
Apamin
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Apamine |
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Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic acti... |
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T20396 |
Levadopa Related Compound A
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6-Hydroxydopa, L-,L-Hydroxydopa |
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Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent... |
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T80704 |
α-Pompilidotoxin
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α-PMTX |
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α-Pompilidotoxin (α-PMTX), a neurotoxin sourced from Anoplius samanensis venom, reversibly and dose-dependently enhances excitatory postsynaptic currents (EPSCs), serving as a valuable tool in neuroscience research [1]. |
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T80427 |
Jingzhaotoxin-II
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Sodium Channel
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Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodium channels (VGSC), notably slowing the rapid inactivation of TTX-resi... |
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T75746 |
Apamin TFA
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Apamin TFA, also known as Apamine TFA, is an 18-amino acid peptide neurotoxin derived from apitoxin (bee venom). It functions as a specifically selective blocker of Ca2+-activated K+ (SK) channels and demonstrates anti-i... |
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T69578 |
D-Ibotenic Acid
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D-Ibotenic Acid is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere. It ... |
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T83136 |
Alpha-Cobratoxin
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Alpha-Cobratoxin, a neurotoxin isolated from Thai cobra venom, displays neuromodulatory, antiviral, and analgesic activities, as well as potent immunosuppressive effects in the treatment of acute and chronic multiple scl... |
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T80426 |
Jingzhaotoxin-IX
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Sodium Channel
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Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues. It inhibits both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms of voltage-gated sodium channels, as well a... |
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T80530 |
Spinoxin
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SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13 |
Potassium Channel
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Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges. It acts as a potent inhibitor of the Kv1.3 potassium channel with an IC 50 value of... |
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T81519 |
Pentapeptide-3
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Pentapeptide-3, a pentapeptide fragment derived from waglerin-1 neurotoxin, is sourced from Temple Viper venom. This compound serves as a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), blocking ner... |
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T75856 |
Huwentoxin-IV TFA
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Huwentoxin-IV TFA is a potent, selective blocker of sodium channels, specifically inhibiting neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4 with IC50 values of 26, 150, 338, and 400 nM, respectively. It preferentially targe... |
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T80165 |
α-Conotoxin GID
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α-Conotoxin GID is a paralytic peptide neurotoxin that selectively antagonizes nAChR with IC50 values of 5 nM (α7), 3 nM (α3β2), and 150 nM (α4β2). It is a small, disulfide-rich peptide with the potential for chronic pai... |
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T80166 |
α-Conotoxin BuIA
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α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α... |
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T83894 |
4A7C-301-Nurr1 Agonist
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4A7C-301-Nuclear Receptor-Related 1 |
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The compound 4A7C-301-Nurr1 agonist is a specific agonist for the nuclear receptor-related 1 (Nurr1). By binding to the Nurr1 ligand-binding domain with an IC50 value of 48.22 nM, it enhances the transcriptional activity... |
