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T79088 |
Chlamydia pneumoniae-IN-1
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Antibacterial
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Chlamydia pneumoniae-IN-1 is a benzimidazole analog that inhibits Chlamydia pneumoniae at low concentrations.Chlamydia pneumoniae-IN-1 exhibits antimicrobial activity with a MIC of 12.6 μM against CV-6 strains, and can b... |
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T40417 |
Ethylhydrocupreine hydrochloride
|
Optochin hydrochloride |
Antibacterial
,
Parasite
|
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Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of... |
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T9318 |
TP0586532
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Others
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TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. |
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T11876 |
LpxH-IN-AZ1
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Antibacterial
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T60092 |
CHEMBL1276927
|
N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide,N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide |
Antibacterial
,
Parasite
|
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CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) shows antibacterial and antiparasitic activities against Chlamydia pneumoniae and Leishmania donovani. |
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T77551 |
6'-hydroxydihydrocinchonidine
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Antibiotic
,
Drug Metabolite
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6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae. |
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T4063 |
Delafloxacin
|
ABT492,WQ-3034,RX-3341 |
Antibacterial
,
Antibiotic
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Delafloxacin (WQ-3034) (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. It has potent inhibitory against levofloxacin-resistant Streptococcus pneumoniae strains (MIC: 0.0078-0.125 μg/ml). |
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T38137 |
3,5-Dimethylbenzaldehyde
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Endogenous Metabolite
,
Antifungal
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3,5-Dimethylbenzaldehyde has broad-spectrum antimicrobial activity, inhibiting Bacillus subtilis, Pseudomonas albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. |
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T11265 |
Faropenem daloxate
|
Faropenem medoxil |
Antibacterial
,
Antibiotic
|
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Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and other key pathogens implicated ... |
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T0331L |
Moxifloxacin
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Avelox,Moxeza |
Others
,
Antibacterial
,
Antibiotic
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Moxifloxacin (Avelox) is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae. |
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T2331 |
Solithromycin
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OP-1068,CEM-101 |
Antibacterial
,
Antibiotic
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Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemop... |
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T41275 |
PF-04753299
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Others
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PF-04753299 is a potent and selective inhibitor of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC), demonstrating bactericidal effects against gonococcal isolates. It exhibits inhibitory activity aga... |
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T35449 |
α-(difluoromethyl)-DL-Arginine
|
DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine |
Others
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α-(difluoromethyl)-DL-Arginine (RMI 71897) is an enzyma-activated, irreversible inhibitor of arginine decarboxylase for E. coli (Ki = 800 μM), Pseudomonas aeruginosa, and Klebsiella pneumoniae. At 0.01 mM, it has been sh... |
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T28209 |
NSC65847
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Others
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NSC65847 is a novel dual inhibitor of viral and Streptococcus pneumoniae neuraminidase. |
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T62773 |
OX11
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Others
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OX11 is a selective inhibitor of S. pneumoniae, P. aeruginosa and E. coli bacteria. |
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T70835 |
（4R，9S)-AG 205
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Others
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AG-205 is a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. |
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T5189L |
Omadacycline mesylate
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PTK 0796,PTK-0796,PTK0796 |
Others
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Omadacycline is an aminomethylcycline antibiotic. Omadacycline demonstrated net cidal activity in relation to the initial burden against four strains of Streptococcus pneumoniae. |
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T40088 |
TP0586352
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Others
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TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks. |
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T30826 |
Cgp 31523A
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Cgp-31523A,Cgp31523A |
Others
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CGP 31523a is a new type of aminothiazolyl cephalosporin, which can inhibit Escherichia coli, Klebsiella pneumoniae, Pseudomonas mirabilis, Clostridium diving, Klebsiella acidogenes, Pseudomonas Stuart, Salmonella, and S... |
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T63695 |
Antibacterial agent 90
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Others
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Antibacterial agent 90 (6n) is an antibacterial pleuromutilin derivative that exhibits antibacterial activity against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae. |
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T72330 |
Antibacterial agent 19
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Others
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Antibacterial agent 19 exhibits strong activity against K. pneumoniae, (M-R) S. aureus, and (M-R,V-R) S. aureus, demonstrating minimum inhibitory concentrations (MICs) of 0.022 mg/mL for both K. pneumoniae and (M-R) S. a... |
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T37721 |
Dihydronovobiocin
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Others
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Dihydronovobiocin is a coumarin antibiotic and derivative of novobiocin .1It is active against the bacteriaS. aureus,S. haemolyticus,D. pneumoniae,S. typhosa,K. pneumoniae, andP. multocida(MICs = 0.6, 2, 0.6, 10, 10, and... |
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T25767 |
Lysobactin
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Katanosin A, 7-L-isoleucine-,Katanosin B |
|
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Lysobactin, also known as katanosin B, is an effective antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis. |
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T81737 |
MurF-IN-1
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Others
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MurF-IN-1 (Compound 7) is an inhibitor of the MurF enzyme, exhibiting an inhibitory concentration with a pIC50 value of 5.19 in assays targeting Streptococcus pneumoniae MurF [1]. |
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T80385 |
K11
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K11, an antimicrobial peptide, demonstrates activity against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL) and inhibits bacterial biofilm formation. It also acts synergistically with various antibiotics (Chlorampheni... |
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T75516 |
Seconeolitsine
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Others
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Seconeolitsine, an antibiotic and new antimicrobial agent, inhibits the growth of S. pneumoniae and possesses activity against topoisomerase I (TopA), effectively inhibiting TopA's relaxation activity with an IC50 value ... |
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T38559 |
Competence-Stimulating Peptide-2 (CSP-2)
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Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide synthesized by Streptococcus pneumoniae. ComD2, a compatible receptor of CSP-2, exhibits an EC 50 value of 50.7 nM. |
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T36032 |
Desotamide
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Others
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Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectiv... |
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T63512 |
LpxC-IN-10
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Others
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LpxC-IN-10 is a selective LpxC inhibitor with an MIC of 0.5 μg/mL against E. coli and K. pneumoniae and is capable of being used to study bacterial infections. |
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T80411 |
Bactenecin 5
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Bactenecin 5, a bovine antibacterial peptide, exhibits activity against Escherichia coli, Salmonella typhimurium, and Klebsiella pneumoniae, with minimum inhibitory concentration (MIC) values ranging from 12-25 μg/mL [1]... |
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T80372 |
P1
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P1 is a broad-spectrum antimicrobial peptide exhibiting antibacterial activity against both Gram-positive and Gram-negative bacteria, including B. anthracis spores and Carbapenem-resistant strains of A. baumannii and K. ... |
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T39758 |
ARX-1796
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ARX-1796,AV-006 |
Others
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ARX-1796 (AV-006), an Avibactam prodrug, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemas... |
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T30481 |
BK 218
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BK218,BK-218 |
Others
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BK 218 is a novel cephalosporin, which is active against streptococcus pneumoniae, Haemophilus influenza, and Moraxella catarrase, but has a higher MIC against penicillin-resistant strains. Bk-218 has dual administration... |
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T38333 |
Corynecin I
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Others
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Corynecin I is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It is active against Gram-positive and Gram-negative bacteria with MIC values of 5.2-83 μg/ml for S. sonnei, P. vulgaris, K. pneu... |
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T68438 |
APO-6619
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Others
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APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. AP... |
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T60470 |
KPC-2-IN-2
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Others
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KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor with Ki of 0.038 μM. KPC-2-IN-2 can enhance the activity of cefotaxime in E. coli expressing KPC-2 [1]. |
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T36028 |
Desacetylcefotaxime (potassium salt)
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Others
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Desacetylcefotaxime is an active metabolite of the cephalosporin antibiotic cefotaxime .1It is active against 60 clinical isolates derived from patients with meningitis, includingH. influenzae,S. pneumoniae,S. agalactiae... |
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T38021 |
Obafluorin
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Others
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Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all).
|1. Pu, Y., Lowe, C., Sailer, M., et al.... |
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T72532 |
Ethylhydrocupreine
|
Optochin |
Others
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Ethylhydrocupreine (Optochin), a quinine derivative, exhibits antimicrobial properties against S. pneumoniae and antimalarial capabilities targeting Plasmodium falciparum with an IC50 of 25.75 nM. Additionally, it acts a... |
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T84433 |
Doripenem hydrate
|
S 4661 |
Others
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Doripenem is a broad-spectrum carbapenem antibiotic effective against both Gram-negative and Gram-positive bacteria, such as S. aureus, S. pneumoniae, E. coli, and K. pneumoniae, with minimum inhibitory concentrations (M... |
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T16749 |
Rifalazil
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KRM-1648,ABI-1648 |
DNA/RNA Synthesis
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T38334 |
Corynecin III
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Others
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Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. ... |
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T37888 |
Desacetylcephapirin sodium
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Others
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Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 ... |
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T39296 |
DS86760016
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Others
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DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and ... |
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T39175 |
CSP1
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|
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CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the g... |
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T38259 |
Phenelfamycin E
|
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Others
|
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Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) inc... |
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T28311 |
PD 116152
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PD116,152,PD 116,152,PD116152,PD-116,152,PD-116152 |
Others
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PD 116152 is a highly substituted phenazine with antitumor activity isolated from the culture broth of a Streptomyces sp. The antitumor activity versus murine P388 leukemia is T/C 149. PD 116152 is selectively active ver... |
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T32669 |
Leucomycin a5
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Leukomycin A5,Turimycin H4 |
Others
|
|
Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not a... |
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T60797 |
β-Lactamase-IN-7
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Others
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β-Lactamase-IN-7 (compound 14) effectively inhibit Klebsiella pneumoniae that is a potent inhibitor of VIM-Type metallo-β-lactamase with Ki values of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively [1]. |
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T78673 |
Antibacterial agent 135
|
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Others
|
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Antibacterial Agent 135 (example 7) effectively inhibits various bacteria, including P. aeruginosa, A. baumannii, E. coli, and K. pneumoniae, with a minimum inhibitory concentration (MIC) greater than 64 μg/mL [1]. |
