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T7598 |
Calcium N5-methyltetrahydrofolate
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NSC173328 |
Others
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Antifolate
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Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers |
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T29461 |
5-Methyltetrahydrofolate triglutamate
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5-Me-Thf(glu)3 |
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5-Methyltetrahydrofolate triglutamate is a form of folic acid. |
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T11103 |
DS18561882
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Others
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DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063. |
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T8003 |
Methotrexate disodium
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Apoptosis
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Dehydrogenase
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DNA/RNA Synthesis
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Antifolate
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Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |
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T20339 |
7-Hydroxymethotrexate
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NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 |
Drug Metabolite
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7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibitin... |
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T24985 |
5-Monobutyl methotrexate
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NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986 |
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5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of ... |
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T69257 |
Methotrexate diethyl ester
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Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthes... |
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T69177 |
Methotrexate di-n-butyl ester
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Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synt... |
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T25374 |
Emofolin sodium
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NSC139490,MeTHHF disodium,NSC-139490,NSC 139490 |
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Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition o... |
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T76131 |
Sarcosine oxidase
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Sarcosine oxidase (SAO) catalyzes the oxidative demethylation of sarcosine, producing glycine, H2O2, and 5,10-CH2-tetrahydrofolate, substances commonly utilized in biochemical reactions [1]. |
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T37998 |
N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)
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N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2
1.... |
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T7730L |
Aminopterin sodium
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NSC739,NSC 739 [as the base],NSC-739 |
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Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affini... |
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T25079 |
Aminopterin N-hydroxysuccinimide ester
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Nhs-aminopterin,N-Hydroxysuccinimide aminopterin |
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Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase... |
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T25981 |
Pralatrexate, (S)-
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Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ... |
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T25980 |
Pralatrexate, (R)-
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Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ... |
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T74009 |
1,1,3-Tribromoacetone
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1,1,3-Tribromoacetone is an impurity of Methotrexate [1]. Methotrexate is an antimetabolite and antifolate drug that blocks the enzyme dihydrofolate reductase, stopping the transformation of folic acid into tetrahydrofol... |
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T32705 |
Levomefolate magnesium
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L-Methylfolate magnesium |
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Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human ... |
