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Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, enzymes (e.g., cAMP-dependent kinases), or ion transporters.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T7813 α-MSH 581-05-5 100%
α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
T60003 AC1-IN-1 2762422-55-7 100%
AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).
T16333 NKY80 299442-43-6 100%
NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50...
T15787 LRE1 1252362-53-0 100%
LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.
T16275 NB001 686301-48-4 98.43%
NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.
T10066 2',5'-Dideoxyadenosine 6698-26-6 98.66%
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).
T2939 Forskolin 66575-29-9 98.83%
Forskolin (Coleonol), a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T16938 ST034307 133406-29-8 99.28%
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
T77502 Wnt pathway inhibitor 3 663213-98-7 99.69%
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies t...
α-MSH
T7813
α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
AC1-IN-1
T60003
AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).
NKY80
T16333
NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50...
LRE1
T15787
LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.
NB001
T16275
NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.
2',5'-Dideoxyadenosine
T10066
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).
Forskolin
T2939
Forskolin (Coleonol), a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
ST034307
T16938
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
Wnt pathway inhibitor 3
T77502
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies t...