Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).
説明 | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM). |
ターゲット&IC50 | Adenylyl cyclase:3 µM |
In vitro | 2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3]. |
In vivo | 2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats [4]. |
細胞研究 | Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3] |
動物実験 | Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3] |
分子量 | 235.24 |
分子式 | C10H13N5O2 |
CAS No. | 6698-26-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.35 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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2',5'-Dideoxyadenosine 6698-26-6 GPCR/G Protein Neuroscience Adenylyl cyclase AChR Adrenergic Receptor P-site 2',5'Dideoxyadenosine cyclase Beta Receptor analog heart adenylyl antiadrenergic Inhibitor Adenylate Cyclase inhibit nucleoside 2',5' Dideoxyadenosine inhibitor