BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	製品名	CAS No.	Purity
T7727	Se-Methylselenocysteine	26046-90-2	98%
T7727	Se-Methylselenocysteine is a drug potentially for the treatment of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 exp...
TN2019	Orobol	480-23-9	98%
TN2019	Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α...
T0186	Docetaxel trihydrate	148408-66-6	98%
T0186	Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T6778	BDA-366	1909226-00-1	98%
T6778	BDA-366 is a potent Bcl2 antagonist, binding Bcl2-BH4 domain with high affinity and selectivity (Ki = 3.3 nM). BDA-366 induces conformational change in Bcl2 that...
T1119	Rasagiline	136236-51-6	98%
T1119	Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
T5S0993	Kurarinone	34981-26-5	98%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
TN3967	Epieriocalyxin A	191545-24-1	98%
TN3967	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
T6034	UMI-77	518303-20-3	98%
T6034	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.
TN1195	17-Hydroxy sprengerinin C	1029017-75-1	98%
TN1195	17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C ...
T77571	Bcl-B inhibitor 1	79220-88-5	98%
T77571	Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.
T5408	BI-3802	2166387-65-9	98%
T5408	BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 value of ≤3 nM. BI-3802 induces the polymerization of BCL...
T25049	Allethrin	584-79-2	98%
T25049	The allethrins are a group of related synthetic compounds utilized in insecticides.
T37518	Diphenyl disulfide	882-33-7	98%
T37518	Diphenyl disulfide shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax pro...
TN2063	Physalin B	23133-56-4	98%
TN2063	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
T2632	A-1210477	1668553-26-1	98%
T2632	A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).
T3344	Ciwujianoside B	114902-16-8	98%
T3344	Ciwujianoside-B is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition.
TN4583	Moringin	73255-40-0	98%
TN4583	Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T9083	TC11	100823-03-8	98%
T9083	TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
T3940	CID5721353	301356-95-6	98%
T3940	CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical si...