| TN2019 |
Orobol
|
480-23-9
|
98%
|
|
|
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms wi...
|
| T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
| T6778 |
BDA-366
|
1909226-00-1
|
98%
|
|
|
BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its an...
|
| T6881 |
LTX-315
|
1345407-05-7
|
98%
|
|
|
LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
|
| TN1195 |
17-Hydroxy sprengerinin C
|
1029017-75-1
|
98%
|
|
|
17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C ...
|
| T5408 |
BI-3802
|
2166387-65-9
|
98%
|
|
|
BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization o...
|
| T25049 |
Allethrin
|
584-79-2
|
98%
|
|
|
Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent.
|
| T77332 |
TV 3279
|
209394-29-6
|
98%
|
|
|
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SO...
|
| TN4583 |
Moringin
|
73255-40-0
|
98%
|
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
|
| T3940 |
CID5721353
|
301356-95-6
|
98%
|
|
|
CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bin...
|
| T60008 |
BCL6-IN-6
|
2408882-54-0
|
98%
|
|
|
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressor...
|
| T0186 |
Docetaxel trihydrate
|
148408-66-6
|
|
|
|
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currentl...
|
| TN3967 |
Epieriocalyxin A
|
191545-24-1
|
|
|
|
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
|
| T2632 |
A-1210477
|
1668553-26-1
|
|
|
|
A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).
|
| T0448 |
(S)-(+)-Ibuprofen
|
51146-56-6
|
100%
|
|
|
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
|
| TP1724L |
PUMA BH3 acetate
|
|
96.64%
|
|
|
PUMA BH3 acetate (PUMA BH3 Free base) is a p53 positive regulator of apoptosis (PUMA) BH3 domain polypeptide that acts as a direct activator of Bak with a Kd of ...
|
| T6396 |
(R)-(-)-Gossypol acetic acid
|
866541-93-7
|
96.73%
|
|
|
(R)-(-)-Gossypol acetic acid (AT101 acetate) , the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0...
|
| T10483 |
Lisaftoclax
|
2180923-05-9
|
97.14%
|
|
|
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lis...
|
| T10487 |
BCL6-IN-3
|
2253878-44-1
|
97.25%
|
|
|
BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has...
|
| TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
