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FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T11428 Glyco-Obeticholic acid 863239-60-5 98%
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
T6344 Sevelamer hydrochloride 152751-57-0 98%
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption....
T2233 GW 4064 278779-30-9 98%
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T77124 Osocimab 2056878-75-0 98%
Osocimab
Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition...
T11661 INT-767 1000403-03-1 98%
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
T6053 Turofexorate Isopropyl 629664-81-9
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T8471 Vonafexor 1192171-69-9 100%
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T2968 Hyodeoxycholic acid 83-49-8 97.26%
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
T8895 Altenusin 31186-12-6 97.93%
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T7436 Cilofexor 1418274-28-8 98%
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T5574 Guggulsterone 95975-55-6 98%
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T27460 GSK2324 1020567-30-9 98.50%
GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
T29078 Ursodeoxycholic acid sodium 2898-95-5 98.55%
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
T2939 Forskolin 66575-29-9 98.83%
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces auto...
T2015 Fexaramine 574013-66-4 98.87%
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T4379 Tropifexor 1383816-29-2 99.3%
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T6690 T0901317 293754-55-9 99.43%
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T31587 DY268 1609564-75-1 99.43%
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 =...
T7886 Nidufexor 1773489-72-7 99.79%
Nidufexor is an agonist for the farnesoid X receptor (FXR).
T13092 Tauro-Obeticholic acid 863239-61-6 99.82%
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
Glyco-Obeticholic acid
T11428
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
Sevelamer hydrochloride
T6344
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption....
GW 4064
T2233
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
Osocimab
T77124
Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition...
INT-767
T11661
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
Turofexorate Isopropyl
T6053
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
Vonafexor
T8471
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
Hyodeoxycholic acid
T2968
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
Altenusin
T8895
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Cilofexor
T7436
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
Guggulsterone
T5574
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
GSK2324
T27460
GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
Ursodeoxycholic acid sodium
T29078
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
Forskolin
T2939
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces auto...
Fexaramine
T2015
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
Tropifexor
T4379
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T0901317
T6690
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
DY268
T31587
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 =...
Nidufexor
T7886
Nidufexor is an agonist for the farnesoid X receptor (FXR).
Tauro-Obeticholic acid
T13092
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
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