GSK-3

Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways. In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (diabetes mellitus type 2), Alzheimer's disease, inflammation, cancer, and bipolar disorder.

Cat. No.	製品名	CAS No.	Purity
T3067	Tideglusib	865854-05-3	98%
T3067	Tideglusib, a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.
T2166	TWS119	601514-19-6	98%
T2166	TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T60472	GSK-3β inhibitor 12	784170-07-6	98%
T60472	GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β inhib...
T77554	4-(2-Bromoacetyl)benzonitrile	20099-89-2	98%
T77554	4-(2-Bromoacetyl)benzonitrile is a ketone derivative that is used as an intermediate in pharmaceuticals and organic synthesis, and inhibits glycogen synthase kin...
T6169	Indirubin	479-41-4	98%
T6169	Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
T17019	TCS 21311	1260181-14-3	98%
T17019	TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively)....
T73331	GSK3-IN-3	331963-27-0	98%
T73331	GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 i...
T73270	GSK3-IN-2	380450-97-5	98%
T73270	GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.
T10608	BRD5648	2056261-42-6	98%
T10608	BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM).
T2873	Ginsenoside Rg2	52286-74-5	98%
T2873	Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
T6659	SB 415286	264218-23-7	98%
T6659	SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
T5956	VP3.15 dihydrobromide	1281681-33-1	98%
T5956	VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1....
T9987	WAY-352753	478482-74-5	98%
T9987	WAY-352753 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.
T11447	GNF4877	2041073-22-5	98%
T11447	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
TN4583	Moringin	73255-40-0	98%
TN4583	Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T9611	PF-04802367	1962178-27-3	98%
T9611	PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It s...
T77671	GSK3a-IN-38	1062138-03-7	98%
T77671	GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.
T9025	KY19382	2226664-93-1	98%
T9025	KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through i...
T69188	Aloisine B	496864-14-3	98%
T69188	Aloisine B inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiviral activit...