Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T3075 | FLI-06 | 313967-18-9 | 98% |
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FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM). | ||||
T71534L | CIA-1 (Free base) | 452087-38-6 | 98% |
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CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhib... | ||||
T6861 | IMR-1 | 310456-65-6 | 98% |
|
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | ||||
T6870 | L-685458 | 292632-98-5 | 98% |
|
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. | ||||
T16133 | MRK-560 | 677772-84-8 | 98% |
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. | ||||
T76788 | Demcizumab | 1243262-17-0 | 98% |
Demcizumab
|
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, bo... | ||||
T76698 | Rovalpituzumab | 1613313-01-1 | 98% |
Rovalpituzumab
|
Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjug... | ||||
T3540 | IMR-1A | 331862-41-0 |
|
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IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | ||||
T3399 | Psoralidin | 18642-23-4 |
|
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Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p... | ||||
TQ0026 | MDR-1339 | 1018946-38-7 |
|
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MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. | ||||
T9641 | Aβ42-IN-2 | 1914989-80-2 | 100% |
|
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1]. | ||||
T14673 | BMS 299897 | 290315-45-6 | 100% |
|
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr... | ||||
T21890 | JLK6 | 62252-26-0 | 96.50% |
|
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling | ||||
T31987 | Gossypolone | 4547-72-2 | 96.66% |
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Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis. | ||||
T6063 | LY-411575 | 209984-57-6 | 97.03% |
|
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.3... | ||||
T4S1990 | Carvacrol | 499-75-2 | 97.52% |
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1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effect... | ||||
T6274 | RO4929097 | 847925-91-1 | 97.68% |
|
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM). | ||||
T10532 | BI-1408 | 2231075-94-6 | 97.91% |
|
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42). | ||||
T2262 | Itanapraced | 749269-83-8 | 98% |
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Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM). | ||||
T13410 | ZLDI-8 | 667880-38-8 | 98.09% |
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ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. |