Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
説明 | IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. |
ターゲット&IC50 | IMR-1:6 μMol/L. |
In vitro | IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). |
In vivo | The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. |
分子量 | 325.36 |
分子式 | C13H11NO5S2 |
CAS No. | 331862-41-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.23 mg/mL (13 mM)
You can also refer to dose conversion for different animals. 詳細
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IMR-1A 331862-41-0 Metabolism Neuroscience Proteases/Proteasome Stem Cells Drug Metabolite Gamma-secretase Notch Inhibitor inhibit IMR1A IMR 1A inhibitor